| *608113 | ||||||
| SARCOGLYCAN, ZETA; SGCZ | ||||||
| Alternative titles; symbols | ||||||
| ZSG1 ZETA-SARCOGLYCAN | ||||||
| HGNC Approved Gene Symbol: SGCZ | ||||||
| TEXT | ||||||
| Cloning | ||||||
| By searching electronic databases and by RT-PCR experiments, Wheeler et al. (2002) identified the murine zeta-sarcoglycan (SGCZ) gene. The gene shares 56% identity and 74% similarity in amino acid sequence both to gamma-sarcoglycan (SGCG; 608896) and delta-sarcoglycan (SGCD; 601411). It is also 89% identical to human SGCZ on the nucleotide level. | ||||||
| Gene Structure | ||||||
| Wheeler et al. (2002) determined that human SGCZ shares the same intron-exon organization as the gamma- and delta-sarcoglycan genes. | ||||||
| Animal Model | ||||||
| Wheeler et al. (2002) generated a zeta-sarcoglycan-specific antibody and found that zeta-sarcoglycan associated with other members of the sarcoglycan complex at the murine plasma membrane. Additionally, zeta-sarcoglycan was reduced at the membrane in 2 mouse models of muscular dystrophy, gsg -/- (LGMD2C) and dsg -/- (SGCD). Zeta-sarcoglycan was also found as a component of the vascular smooth muscle sarcoglycan complex. The authors proposed that zeta-sarcoglycan is an integral component of the sarcoglycan complex and, as such, may be important in the pathogenesis of muscular dystrophy. | ||||||
| Mapping | ||||||
| Based on homology to the murine gene, Wheeler et al. (2002) localized the human gene to chromosome 8p22 by searching electronic databases. | ||||||
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