DO: 0050925;
Anderson (1966) observed appendiceal carcinoid in father and daughter. Eschbach and Rinaldo (1962) reported fatal malignant carcinoid of the ileum in brother and sister. Duodenal carcinoid occurs with multiple endocrine neoplasia (131100, 162300, 171400).
Karanjawala et al. (2000) reported the first account of an individual with apparently nonmosaic complete maternal isodisomy of chromosome 8. The individual was identified during routine genotyping in a genomewide search for type II diabetes susceptibility genes, although he did not have diabetes. At age 26 years, the patient underwent surgical removal of an invasive ileal carcinoid tumor located about 1.5 m from the ileocecal junction. Metastases were noted in 4 regional lymph nodes. The patient had not had symptoms of carcinoid syndrome (cutaneous flushing, diarrhea, bronchial constriction) and the pre- and postoperative serotonin levels remained normal for 4 years.
For discussion of a possible association of midgut carcinoids and Merkel cell carcinomas and variation in the SDHD gene, see 602690.0011 and 602690.0019.
Anderson, R. E. A familial instance of appendiceal carcinoid. Am. J. Surg. 111: 738-740, 1966. [PubMed: 5936207] [Full Text: https://doi.org/10.1016/0002-9610(66)90053-5]
Debelenko, L. V., Brambilla, E., Agarwal, S. K., Swalwell, J. I., Kester, M. B., Lubensky, I. A., Zhuang, Z., Guru, S. C., Manickam, P., Olufemi, S.-E., Chandrasekharappa, S. C., Crabtree, J. S., Kim, Y. S., Heppner, C., Burns, A. L., Spiegel, A. M., Marx, S. J., Liotta, L. A., Collins, F. S., Travis, W. D., Emmert-Buck, M. R. Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung. Hum. Molec. Genet. 6: 2285-2290, 1997. [PubMed: 9361035] [Full Text: https://doi.org/10.1093/hmg/6.13.2285]
Eschbach, J. W., Rinaldo, J. A., Jr. Metastatic carcinoid: a familial occurrence. Ann. Intern. Med. 57: 647-650, 1962.
Karanjawala, Z. E., Kaariainen, H., Ghosh, S., Tannenbaum, J., Martin, C., Ally, D., Tuomilehto, J., Valle, T., Collins, F. S. Complete maternal isodisomy of chromosome 8 in an individual with an early-onset ileal carcinoid tumor. Am. J. Med. Genet. 93: 207-210, 2000. [PubMed: 10925383] [Full Text: https://doi.org/10.1002/1096-8628(20000731)93:3<207::aid-ajmg9>3.0.co;2-a]
Moertel, C. G., Dockerty, M. B. Familial occurrence of metastasizing carcinoid tumors. Ann. Intern. Med. 78: 389-390, 1973. [PubMed: 4694894] [Full Text: https://doi.org/10.7326/0003-4819-78-3-389]