Alternative titles; symbols
HGNC Approved Gene Symbol: CRHBP
Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38) : 5:76,953,045-76,981,159 (from NCBI)
The CRH-binding protein inactivates corticotropin-releasing hormone (CRH; 122560), a potent stimulator of synthesis and secretion of preopiomelanocortin (176830)-derived peptides, thereby preventing inappropriate pituitary-adrenal stimulation in pregnancy (Potter et al., 1991).
Potter et al. (1991) isolated and partially purified the binding protein and cloned and characterized its cDNA from human liver and rat brain. Expression of the cDNAs in COS-7 cells showed that the protein binds CRH with the same affinity as the native protein. Furthermore, the recombinant binding protein inhibited CRH binding to a CRH antibody and inhibited CRH-induced release of ACTH by pituitary cells in vitro.
Asakura et al. (1997) found that the thecal compartment of the human ovary contains a CRF system endowed with CRF, CRF1 (122561), and CRFBP.
Behan et al. (1993) demonstrated that the human CRHBP gene consists of 7 exons and 6 introns.
Behan et al. (1993) mapped the human CRHBP gene to chromosome 5q by Southern blot analysis of DNA from somatic cell hybrids. They mapped the murine counterpart to the distal region of chromosome 13 by means of analysis of interspecific backcross matings.
Studying somatic cell hybrids that contained various deletions of chromosome 5, Vamvakopoulos et al. (1995) regionalized the assignment of the CRHBP gene to 5q11.2-q13.3.
Asakura, H., Zwain, I. H., Yen, S. S. C. Expression of genes encoding corticotropin-releasing factor (CRF), type 1 CRF receptor, and CRF-binding protein and localization of the gene products in the human ovary. J. Clin. Endocr. Metab. 82: 2720-2725, 1997. [PubMed: 9253360] [Full Text: https://doi.org/10.1210/jcem.82.8.4119]
Behan, D. P., Potter, E., Lewis, K. A., Jenkins, N. A., Copeland, N., Lowry, P. J., Vale, W. W. Cloning and structure of the human corticotropin releasing factor-binding protein gene (CRHBP). Genomics 16: 63-68, 1993. Note: Erratum: Genomics 19: 198 only, 1994. [PubMed: 8198617] [Full Text: https://doi.org/10.1006/geno.1993.1141]
Potter, E., Behan, D. P., Fischer, W. H., Linton, E. A., Lowry, P. J., Vale, W. W. Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins. Nature 349: 423-426, 1991. [PubMed: 1846945] [Full Text: https://doi.org/10.1038/349423a0]
Vamvakopoulos, N. C., Sioutopoulou, T. O., Durkin, S. A., Nierman, W. C., Wasmuth, J. J., McPherson, J. D. Mapping the human corticotropin releasing hormone binding protein gene (CRHBP) to the long arm of chromosome 5 (5q11.2-q13.3). Genomics 25: 325-327, 1995. [PubMed: 7774945] [Full Text: https://doi.org/10.1016/0888-7543(95)80151-b]