Entry - *176420 - PREGNANCY ZONE PROTEIN; PZP - OMIM

 
 
* 176420

PREGNANCY ZONE PROTEIN; PZP


Alternative titles; symbols

COMPLEMENT COMPONENT 3- AND PREGNANCY ZONE PROTEIN-LIKE ALPHA-2-MACROGLOBULIN DOMAIN-CONTAINING PROTEIN 6; CPAMD6
C3- AND PZP-LIKE ALPHA-2-MACROGLOBULIN DOMAIN-CONTAINING PROTEIN 6


HGNC Approved Gene Symbol: PZP

Cytogenetic location: 12p13.31   Genomic coordinates (GRCh38) : 12:9,136,472-9,208,395 (from NCBI)


TEXT

▼ Description

Pregnancy zone protein (PZP), one of the major pregnancy-associated plasma proteins, was described by Smithies (1959), who used zone-electrophoresis in starch gels. PZP is a prominent constituent of late-pregnancy sera. In healthy, nonpregnant females and in males, PZP is present in trace amounts only: females, 10-30 mg/l; males, less than 10 mg/l. During pregnancy, PZP levels may reach 1000-1400 mg/l just before term (summary by Sottrup-Jensen et al., 1984).


▼ Cloning and Expression

Sottrup-Jensen et al. (1984) showed that PZP closely resembles alpha-2-macroglobulin (103950) in structure. Both have a quaternary structure of 2 covalently bound 180-kD subunits which are further noncovalently assembled into a tetramer of 720 kD. Amino acid sequence of the 2 proteins are extensively homologous.


▼ Mapping

Marynen et al. (1989) used in situ hybridization and somatic cell hybrid DNA analysis to demonstrate that PZP, alpha-2-macroglobulin, and an alpha-2-macroglobulin pseudogene mapped to human chromosome 12p13-p12.2.

▼ REFERENCES

  1. Marynen, P., Zhang, J., Devriendt, K., Cassiman, J.-J. Alpha-2-macroglobulin, pregnancy zone protein and an alpha-2-macroglobulin pseudogene map to chromosome 12p12.2-13. (Abstract) Cytogenet. Cell Genet. 51: 1040 only, 1989.

  2. Smithies, O. Zone electrophoresis in starch gels and its application to studies of serum proteins. Adv. Protein Chem. 14: 65-113, 1959. [PubMed: 13832188, related citations] [Full Text]

  3. Sottrup-Jensen, L., Folkersen, J., Kristensen, T., Tack, B. F. Partial primary structure of human pregnancy zone protein: extensive sequence homology with human alpha-2-macroglobulin. Proc. Nat. Acad. Sci. 81: 7353-7357, 1984. [PubMed: 6209714, related citations] [Full Text]


Creation Date:
Victor A. McKusick : 6/2/1986
Edit History:
carol : 03/25/2016
alopez : 9/14/2010
supermim : 3/16/1992
supermim : 3/20/1990
carol : 12/12/1989
ddp : 10/27/1989
root : 6/30/1989
root : 5/31/1989

* 176420

PREGNANCY ZONE PROTEIN; PZP


Alternative titles; symbols

COMPLEMENT COMPONENT 3- AND PREGNANCY ZONE PROTEIN-LIKE ALPHA-2-MACROGLOBULIN DOMAIN-CONTAINING PROTEIN 6; CPAMD6
C3- AND PZP-LIKE ALPHA-2-MACROGLOBULIN DOMAIN-CONTAINING PROTEIN 6


HGNC Approved Gene Symbol: PZP

Cytogenetic location: 12p13.31   Genomic coordinates (GRCh38) : 12:9,136,472-9,208,395 (from NCBI)


TEXT

Description

Pregnancy zone protein (PZP), one of the major pregnancy-associated plasma proteins, was described by Smithies (1959), who used zone-electrophoresis in starch gels. PZP is a prominent constituent of late-pregnancy sera. In healthy, nonpregnant females and in males, PZP is present in trace amounts only: females, 10-30 mg/l; males, less than 10 mg/l. During pregnancy, PZP levels may reach 1000-1400 mg/l just before term (summary by Sottrup-Jensen et al., 1984).


Cloning and Expression

Sottrup-Jensen et al. (1984) showed that PZP closely resembles alpha-2-macroglobulin (103950) in structure. Both have a quaternary structure of 2 covalently bound 180-kD subunits which are further noncovalently assembled into a tetramer of 720 kD. Amino acid sequence of the 2 proteins are extensively homologous.


Mapping

Marynen et al. (1989) used in situ hybridization and somatic cell hybrid DNA analysis to demonstrate that PZP, alpha-2-macroglobulin, and an alpha-2-macroglobulin pseudogene mapped to human chromosome 12p13-p12.2.

REFERENCES

  1. Marynen, P., Zhang, J., Devriendt, K., Cassiman, J.-J. Alpha-2-macroglobulin, pregnancy zone protein and an alpha-2-macroglobulin pseudogene map to chromosome 12p12.2-13. (Abstract) Cytogenet. Cell Genet. 51: 1040 only, 1989.

  2. Smithies, O. Zone electrophoresis in starch gels and its application to studies of serum proteins. Adv. Protein Chem. 14: 65-113, 1959. [PubMed: 13832188] [Full Text: https://doi.org/10.1016/s0065-3233(08)60609-9]

  3. Sottrup-Jensen, L., Folkersen, J., Kristensen, T., Tack, B. F. Partial primary structure of human pregnancy zone protein: extensive sequence homology with human alpha-2-macroglobulin. Proc. Nat. Acad. Sci. 81: 7353-7357, 1984. [PubMed: 6209714] [Full Text: https://doi.org/10.1073/pnas.81.23.7353]


Creation Date:
Victor A. McKusick : 6/2/1986

Edit History:
carol : 03/25/2016
alopez : 9/14/2010
supermim : 3/16/1992
supermim : 3/20/1990
carol : 12/12/1989
ddp : 10/27/1989
root : 6/30/1989
root : 5/31/1989



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 17, 2024