Alternative titles; symbols
HGNC Approved Gene Symbol: ZNF7
Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38) : 8:144,827,560-144,847,508 (from NCBI)
On the basis of sequence similarity in the repeated zinc finger domain, Lania et al. (1990) identified and characterized 2 human cDNA clones, designated ZNF7 and ZNF8, both of which encoded proteins containing potential finger-like nucleic acid binding motifs. The predicted 686-amino acid ZNF7 protein contains 15 zinc finger domains that comprise nearly 70% of the protein. Northern blot analysis revealed that ZNF7 is expressed as 2.8- and 3.3-kb mRNAs in a variety of human cell lines.
By in situ hybridization, Lania et al. (1990) localized ZNF7 to 8q24 and ZNF8 to 20q13. Bray et al. (1991) likewise mapped ZNF7 to 8qter by chromosomal in situ suppression hybridization with fluorescent probe detection. Bray et al. (1991) determined that the genomic locus designated ZNF7 corresponds to KOX4 in the set of 30 zinc finger protein-encoding cDNAs (KOX1-KOX30) previously isolated from a T-cell library (Thiesen, 1990). They concluded that the human genome contains many, probably several hundred, zinc finger genes with consensus his/cys (H/C) link regions.
Huebner et al. (1993) confirmed the assignment of ZNF7 to chromosome 8q24 by analysis of rodent/human somatic cell hybrids and by in situ hybridization. They showed that ZNF7 is telomeric to the MYC locus (190080).
Bray, P., Lichter, P., Thiesen, H.-J., Ward, D. C., Dawid, I. B. Characterization and mapping of human genes encoding zinc finger proteins. Proc. Nat. Acad. Sci. 88: 9563-9567, 1991. [PubMed: 1946370] [Full Text: https://doi.org/10.1073/pnas.88.21.9563]
Huebner, K., Druck, T., LaForgia, S., Lasota, J., Croce, C. M., Lanfrancone, L., Donti, E., Pengue, G., La Mantia, G., Pelicci, P.-G., Lania, L. Chromosomal localization of four human zinc finger cDNAs. Hum. Genet. 91: 217-222, 1993. [PubMed: 8478004] [Full Text: https://doi.org/10.1007/BF00218259]
Lania, L., Donti, E., Pannuti, A., Pascucci, A., Pengue, G., Feliciello, I., La Mantia, G., Lanfrancone, L., Pelicci, P.-G. cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes. Genomics 6: 333-340, 1990. [PubMed: 2106481] [Full Text: https://doi.org/10.1016/0888-7543(90)90574-e]
Thiesen, H.-J. Multiple genes encoding zinc finger domains are expressed in human T cells. New Biologist 2: 363-374, 1990. [PubMed: 2288909]