Alternative titles; symbols
HGNC Approved Gene Symbol: ZNF24
Cytogenetic location: 18q12.2 Genomic coordinates (GRCh38) : 18:35,332,227-35,344,420 (from NCBI)
Using PCR primers based on conserved sequences of Kruppel-like genes to screen an acute promyelocytic leukemia cell line, Han et al. (1999) isolated cDNAs encoding ZNF24, which they termed ZNF191. The deduced 368-amino acid protein contains 4 tandemly repeated C-terminal zinc finger motifs with interspersed conserved knuckle sequences, as well as an N-terminal SCAN box, which is enriched in hydrophobic and negatively charged residues and is also found in ZNF174 (603900) and ZNF165 (600834). Northern blot and RT-PCR analyses revealed expression of 6.0- and 2.5-kb transcripts in all tissues tested except heart.
By functional analysis, Han et al. (1999) showed that the ZNF191 SCAN box has no activity in yeast but acts as a transrepressor in mammalian cell lines.
Rousseau-Merck et al. (1991) mapped the ZNF24 (KOX17) gene to 18q12 by somatic cell hybrid analysis and in situ chromosomal hybridization.
Han, Z.-G., Zhang, Q.-H., Ye, M., Kan, L.-X., Gu, B.-W., He, K.-L., Shi, S.-L., Zhou, J., Fu, G., Mao, M., Chen, S.-J., Yu, L., Chen, Z. Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. J. Biol. Chem. 274: 35741-35748, 1999. [PubMed: 10585455] [Full Text: https://doi.org/10.1074/jbc.274.50.35741]
Rousseau-Merck, M. F., Huebner, K., Berger, R., Thiesen, H. J. Chromosomal localization of two human zinc finger protein genes, ZNF24 (KOX17) and ZNF29 (KOX26), to 18q12 and 17p13-p12, respectively. Genomics 9: 154-161, 1991. [PubMed: 2004757] [Full Text: https://doi.org/10.1016/0888-7543(91)90233-5]