HGNC Approved Gene Symbol: ZNF69
Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38) : 19:11,887,782-11,980,222 (from NCBI)
By hybridization to a panel of somatic cell hybrids containing various deletions of chromosome 22, Aubry et al. (1992) mapped the genes encoding 2 zinc finger proteins to the short arm of chromosome 22 and 4 others to the 22q11.2 region. Hitherto, the short arms of acrocentric chromosomes were thought to encode only ribosomal RNA genes. The genes assigned to 22p were ZNF72 (194546) and ZNF73 (194547); those assigned to 22q11.2 were ZNF69, ZNF70 (194544), ZNF71 (194545), and ZNF74 (194548). It was later determined that the ZNF71 gene resides on chromosome 19q13. In addition, Gross (2011) mapped the ZNF69 gene to chromosome 19p13.2 based on an alignment of the ZNF69 sequence (GenBank BC051309) with the genomic sequence (GRCh37).
Aubry, M., Marineau, C., Zhang, F. R., Zahed, L., Figlewicz, D., Delattre, O., Thomas, G., de Jong, P. J., Julien, J.-P., Rouleau, G. A. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). Genomics 13: 641-648, 1992. [PubMed: 1639391] [Full Text: https://doi.org/10.1016/0888-7543(92)90135-f]
Gross, M. B. Personal Communication. Baltimore, Md. 2/7/2011.