HGNC Approved Gene Symbol: ZNF74
Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38) : 22:20,394,151-20,408,455 (from NCBI)
Aubry et al. (1993) found that the ZNF74 gene was hemizygously deleted in 23 out of 24 DiGeorge syndrome (188400) patients tested. ZNF74 mRNA transcripts were detected in human and mouse embryos but not in adult tissues. Sequence analysis of a corresponding cDNA demonstrated an open reading frame encoding 12 zinc finger motifs of the Kruppel/TFIIIA type, as well as N-terminal and C-terminal non-zinc finger domains. Changes in dosage of this putative transcription factor occurring with deletion of ZNF74 may be involved in DiGeorge developmental anomalies.
Aubry et al. (1992) mapped the ZNF74 gene to chromosome 22q11.2 by hybridization to a panel of somatic cell hybrids containing various deletions of chromosome 22.
Aubry, M., Demczuk, S., Desmaze, C., Aikem, M., Aurias, A., Julien, J.-P., Rouleau, G. A. Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome. Hum. Molec. Genet. 2: 1583-1587, 1993. [PubMed: 8268910] [Full Text: https://doi.org/10.1093/hmg/2.10.1583]
Aubry, M., Marineau, C., Zhang, F. R., Zahed, L., Figlewicz, D., Delattre, O., Thomas, G., de Jong, P. J., Julien, J.-P., Rouleau, G. A. Cloning of six new genes with zinc finger motifs mapping to short and long arms of human acrocentric chromosome 22 (p and q11.2). Genomics 13: 641-648, 1992. [PubMed: 1639391] [Full Text: https://doi.org/10.1016/0888-7543(92)90135-f]