HGNC Approved Gene Symbol: ZNF121
Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38) : 19:9,560,329-9,584,504 (from NCBI)
Chen et al. (1993) screened a human brain cDNA library with an oligonucleotide complementary to the conserved 'linker' sequence between adjacent zinc fingers. The insert of 1 positive clone of 1,226 nucleotides contained a novel open reading frame, designated ZNF121, with 9 zinc finger motifs; in addition, 10 repeats of the pentanucleotide sequence (ATTTT) were found 223 nucleotides after a stop codon and were followed by an Alu repeat. The pentanucleotide repeat was polymorphic in the CEPH families, with 7 alleles ranging in size from 147 to 197 nucleotides.
Chen et al. (1993) mapped the ZNF121 gene to chromosome 19 by analysis of somatic cell hybrid panels. The polymorphic locus was designated D19S204. Using the polymorphism, Chen et al. (1993) showed that it was strongly linked to markers on 19p in an area in which other zinc finger sequences and multiple cosmid clones containing zinc fingers had previously been localized.
Chen, H., Kalaitsidaki, M., Warren, A. C., Avramopoulos, D., Antonarakis, S. E. A novel zinc finger cDNA with a polymorphic pentanucleotide repeat (ATTTT)n maps on human chromosome 19p. Genomics 15: 621-625, 1993. [PubMed: 8468057] [Full Text: https://doi.org/10.1006/geno.1993.1116]