Entry - 269800 - SENILE PLAQUE FORMATION - OMIM

 
 
269800

SENILE PLAQUE FORMATION


Clinical Synopsis
 

Neuro
- Senile plaques
Inheritance
- ? Autosomal recessive
▲ Close

▼ TEXT

Constantinidis and De Ajuriaguerra (1965) studied the brain from 64 elderly persons, from 30 families, with various psychiatric diagnoses, for the presence of senile plaques independent of associated cerebral lesions. Of 29 pairs of sibs, 22 pairs had senile plaques, 4 pairs were unaffected, and 3 pairs had 1 affected. Although the authors postulated recessive inheritance, it should be noted that of 10 two-generation observations, parent and child were affected in 3, and 1 generation only in 7.


▼ REFERENCES

  1. Constantinidis, J., De Ajuriaguerra, J. L'incidence familiale des plaques seniles. Confin. Psychiat. 8: 130-137, 1965. [PubMed: 5886992, related citations]


Creation Date:
Victor A. McKusick : 6/4/1986
Edit History:
mimadm : 3/12/1994
supermim : 3/17/1992
supermim : 3/20/1990
ddp : 10/27/1989
marie : 3/25/1988
reenie : 6/4/1986

269800

SENILE PLAQUE FORMATION



TEXT

Constantinidis and De Ajuriaguerra (1965) studied the brain from 64 elderly persons, from 30 families, with various psychiatric diagnoses, for the presence of senile plaques independent of associated cerebral lesions. Of 29 pairs of sibs, 22 pairs had senile plaques, 4 pairs were unaffected, and 3 pairs had 1 affected. Although the authors postulated recessive inheritance, it should be noted that of 10 two-generation observations, parent and child were affected in 3, and 1 generation only in 7.


REFERENCES

  1. Constantinidis, J., De Ajuriaguerra, J. L'incidence familiale des plaques seniles. Confin. Psychiat. 8: 130-137, 1965. [PubMed: 5886992]


Creation Date:
Victor A. McKusick : 6/4/1986

Edit History:
mimadm : 3/12/1994
supermim : 3/17/1992
supermim : 3/20/1990
ddp : 10/27/1989
marie : 3/25/1988
reenie : 6/4/1986



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 30, 2024