Entry - *300024 - ZINC FINGER PROTEIN 157; ZNF157 - OMIM

 
 
* 300024

ZINC FINGER PROTEIN 157; ZNF157


HGNC Approved Gene Symbol: ZNF157

Cytogenetic location: Xp11.3   Genomic coordinates (GRCh38) : X:47,370,578-47,414,498 (from NCBI)


TEXT

▼ Cloning and Expression

Derry et al. (1995) cloned and characterized the cDNA for a 506-amino acid putative zinc finger family transcription factor designated ZNF157. Northern blots detected a weak 3.5-kb transcript in a transformed B-cell line and a T-cell line.


▼ Gene Structure

Derry et al. (1995) determined that the ZNF157 gene contains 4 exons and spans over 20 kb of genomic DNA. Exons 2 and 3 contain KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins. Exon 4 contains 12 zinc finger domains and linking motifs similar to those of proteins of the Kruppel family.


▼ Mapping

Derry et al. (1995) mapped the ZNF157 gene to a YAC that also contains SYN1 (313440), TIMP (305370), ARAF1 (311010) and PFC (300383). This YAC is part of a contig of less than 1 Mb that also contains ZNF41 (314995), ZNF21 (314993) and ZNF81 (314998) and was mapped to Xp11.2. The gene order is tel-ZNF157/ZNF41-ZNF21/ZNF81-cen.


▼ REFERENCES

  1. Derry, J. M. J., Jess, U., Francke, U. Cloning and characterization of a novel zinc finger gene in Xp11.2. Genomics 30: 361-365, 1995. [PubMed: 8586441, related citations] [Full Text]


Creation Date:
Alan F. Scott : 2/11/1996
Edit History:
carol : 11/28/2011
alopez : 7/7/2010
joanna : 2/2/2009
dkim : 6/26/1998
alopez : 1/28/1998
terry : 4/17/1996
mark : 2/11/1996
mark : 2/11/1996

* 300024

ZINC FINGER PROTEIN 157; ZNF157


HGNC Approved Gene Symbol: ZNF157

Cytogenetic location: Xp11.3   Genomic coordinates (GRCh38) : X:47,370,578-47,414,498 (from NCBI)


TEXT

Cloning and Expression

Derry et al. (1995) cloned and characterized the cDNA for a 506-amino acid putative zinc finger family transcription factor designated ZNF157. Northern blots detected a weak 3.5-kb transcript in a transformed B-cell line and a T-cell line.


Gene Structure

Derry et al. (1995) determined that the ZNF157 gene contains 4 exons and spans over 20 kb of genomic DNA. Exons 2 and 3 contain KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins. Exon 4 contains 12 zinc finger domains and linking motifs similar to those of proteins of the Kruppel family.


Mapping

Derry et al. (1995) mapped the ZNF157 gene to a YAC that also contains SYN1 (313440), TIMP (305370), ARAF1 (311010) and PFC (300383). This YAC is part of a contig of less than 1 Mb that also contains ZNF41 (314995), ZNF21 (314993) and ZNF81 (314998) and was mapped to Xp11.2. The gene order is tel-ZNF157/ZNF41-ZNF21/ZNF81-cen.


REFERENCES

  1. Derry, J. M. J., Jess, U., Francke, U. Cloning and characterization of a novel zinc finger gene in Xp11.2. Genomics 30: 361-365, 1995. [PubMed: 8586441] [Full Text: https://doi.org/10.1006/geno.1995.0031]


Creation Date:
Alan F. Scott : 2/11/1996

Edit History:
carol : 11/28/2011
alopez : 7/7/2010
joanna : 2/2/2009
dkim : 6/26/1998
alopez : 1/28/1998
terry : 4/17/1996
mark : 2/11/1996
mark : 2/11/1996



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 17, 2024