HGNC Approved Gene Symbol: PLAC1
Cytogenetic location: Xq26.3 Genomic coordinates (GRCh38) : X:134,565,838-134,764,322 (from NCBI)
By sequencing about 1 Mb of human genomic DNA at Xq26, Cocchia et al. (2000) isolated a novel gene, which they designated PLAC1. PLAC1 encodes a deduced 212-amino acid protein that shares 60% sequence identity with mouse Plac1. The human and mouse proteins contain a signal peptide and a ZP3 motif. Northern blot analysis detected placenta-restricted expression of a 1.7-kb PLAC1 mRNA transcript. In situ hybridization studies in mouse detected Plac1 expression from 7.5 to 14.5 days postcoitum in ectoplacental cone, giant cells, and labyrinthine trophoblasts.
Cocchia et al. (2000) determined that the PLAC1 gene contains 3 predicted exons.
Cocchia et al. (2000) mapped the PLAC1 gene to Xq26, approximately 65 kb telomeric of the HPRT gene (308000). PLAC1 is transcribed in the telomeric to centromeric direction, opposite to the orientation of HPRT. Cocchia et al. (2000) found that the mouse Plac1 gene also maps near the Hprt gene on the X chromosome.
Cocchia, M., Huber, R., Pantano, S., Chen, E. Y., Ma, P., Forabosco, A., Ko, M. S. H., Schlessinger, D. PLAC1, an Xq26 gene with placenta-specific expression. Genomics 68: 305-312, 2000. [PubMed: 10995572] [Full Text: https://doi.org/10.1006/geno.2000.6302]