Entry - *300314 - TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR 7-LIKE; TAF7L - OMIM

 
 
* 300314

TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR 7-LIKE; TAF7L


Alternative titles; symbols

TAF7-LIKE RNA POLYMERASE II, TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR, 50-KD
TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR Q; TAF2Q


HGNC Approved Gene Symbol: TAF7L

Cytogenetic location: Xq22.1   Genomic coordinates (GRCh38) : X:101,268,257-101,293,083 (from NCBI)


TEXT

▼ Cloning and Expression

In a systematic search for genes expressed in mouse spermatogonia but not in somatic tissues, Wang et al. (2001) identified 25 genes, 19 of which were novel, that are expressed in only male germ cells. Of the 25 genes, 3 are Y-linked and 10 are X-linked, indicating that the X chromosome has a predominant role in pre-meiotic stages of mammalian spermatogenesis. One of the novel X-linked genes identified was RNA polymerase II TBP-associated factor II (Taf2q), which encodes a protein with testis-specific expression. Wang et al. (2001) identified an orthologous, full-length human TAF2Q cDNA sequence.


▼ Mapping

By radiation hybrid analysis, Wang et al. (2001) mapped the human TAF7L (TAF2Q) gene to the X chromosome.


▼ REFERENCES

  1. Wang, P. J., McCarrey, J. R., Yang, F., Page, D. C. An abundance of X-linked genes expressed in spermatogonia. Nature Genet. 27: 422-426, 2001. [PubMed: 11279525, related citations] [Full Text]


Creation Date:
Ada Hamosh : 3/28/2001
Edit History:
alopez : 04/21/2020
carol : 12/27/2019
carol : 12/20/2001
joanna : 12/5/2001
carol : 3/29/2001
carol : 3/28/2001

* 300314

TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR 7-LIKE; TAF7L


Alternative titles; symbols

TAF7-LIKE RNA POLYMERASE II, TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR, 50-KD
TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR Q; TAF2Q


HGNC Approved Gene Symbol: TAF7L

Cytogenetic location: Xq22.1   Genomic coordinates (GRCh38) : X:101,268,257-101,293,083 (from NCBI)


TEXT

Cloning and Expression

In a systematic search for genes expressed in mouse spermatogonia but not in somatic tissues, Wang et al. (2001) identified 25 genes, 19 of which were novel, that are expressed in only male germ cells. Of the 25 genes, 3 are Y-linked and 10 are X-linked, indicating that the X chromosome has a predominant role in pre-meiotic stages of mammalian spermatogenesis. One of the novel X-linked genes identified was RNA polymerase II TBP-associated factor II (Taf2q), which encodes a protein with testis-specific expression. Wang et al. (2001) identified an orthologous, full-length human TAF2Q cDNA sequence.


Mapping

By radiation hybrid analysis, Wang et al. (2001) mapped the human TAF7L (TAF2Q) gene to the X chromosome.


REFERENCES

  1. Wang, P. J., McCarrey, J. R., Yang, F., Page, D. C. An abundance of X-linked genes expressed in spermatogonia. Nature Genet. 27: 422-426, 2001. [PubMed: 11279525] [Full Text: https://doi.org/10.1038/86927]


Creation Date:
Ada Hamosh : 3/28/2001

Edit History:
alopez : 04/21/2020
carol : 12/27/2019
carol : 12/20/2001
joanna : 12/5/2001
carol : 3/29/2001
carol : 3/28/2001



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 16, 2024