Alternative titles; symbols
HGNC Approved Gene Symbol: MAGEA11
Cytogenetic location: Xq28 Genomic coordinates (GRCh38) : X:149,688,193-149,717,268 (from NCBI)
The MAGEA family consists of 12 genes (MAGEA1 to MAGEA12), of which 6, MAGEA1 (300016), MAGEA2 (300173), MAGEA3 (300174), MAGEA4 (300175), MAGEA6 (300176), and MAGEA12 (300177), are expressed in melanomas and other cancers. For further background information on the MAGEA family, see 300016.
De Plaen et al. (1994) identified the 12 MAGEA genes. MAGEA11 appeared to be a weakly expressed member of the family.
By analysis of cell hybrids, ordered YACs, and cosmids, Rogner et al. (1995) localized the MAGEA cluster to Xq28. They showed that the 12 genes are arranged in 3 clusters within 3.5 Mb.
See 300016 for a discussion of the high frequency of genes on the X chromosome encoding proteins with the MAGE domain as well as other cancer-testis antigen genes (Ross et al., 2005).
De Plaen, E., Arden, K., Traversari, C., Gaforio, J. J., Szikora, J.-P., De Smet, C., Brasseur, F., van der Bruggen, P., Lethe, B., Lurquin, C., Brasseur, R., Chomez, P., De Backer, O., Cavenee, W., Boon, T. Structure, chromosomal localization, and expression of 12 genes of the MAGE family. Immunogenetics 40: 360-369, 1994. [PubMed: 7927540] [Full Text: https://doi.org/10.1007/BF01246677]
Rogner, U. C., Wilke, K., Steck, E., Korn, B., Poustka, A. The melanoma antigen gene (MAGE) family is clustered in the chromosomal band Xq28. Genomics 29: 725-731, 1995. [PubMed: 8575766] [Full Text: https://doi.org/10.1006/geno.1995.9945]
Ross, M. T., Grafham, D. V., Coffey, A. J., Scherer, S., McLay, K., Muzny, D., Platzer, M., Howell, G. R., Burrows, C., Bird, C. P., Frankish, A., Lovell, F. L., and 270 others. The DNA sequence of the human X chromosome. Nature 434: 325-337, 2005. [PubMed: 15772651] [Full Text: https://doi.org/10.1038/nature03440]