Alternative titles; symbols
HGNC Approved Gene Symbol: FAM9B
Cytogenetic location: Xp22.31 Genomic coordinates (GRCh38) : X:9,024,232-9,034,127 (from NCBI)
FAM9B is expressed specifically in testis (Martinez-Garay et al., 2002).
By characterizing a region of chromosome Xp22 involved in a translocation with chromosome 10, followed by EST database analysis and 5-prime RACE of a testis cDNA library, Martinez-Garay et al. (2002) cloned full-length FAM9B. The deduced 186-amino acid protein contains 3 overlapping putative bipartite nuclear localization signals. FAM9B shares 65% amino acid identity with FAM9C (300479), 46% identity with FAM9A (300477), and about 30% identity with rodent Sycp3 (604759). Northern blot analysis of several tissues detected expression only in testis. Fluorescence-tagged FAM9B localized to the nucleus of transfected COS-7 cells. There was also faint cytoplasmic staining.
Martinez-Garay et al. (2002) determined that the FAM9B gene contains 9 exons and spans about 9 kb.
By genomic sequence analysis, Martinez-Garay et al. (2002) mapped the FAM9B gene to chromosome Xp22.32, near the FAM9A and FAM9C genes and several pseudogenes. They also mapped related genes or pseudogenes to chromosomes Xq28, Yp11.31, 1p36.13, and 8p11.1.
Martinez-Garay, I., Jablonka, S., Sutajova, M., Steuernagel, P., Gal, A., Kutsche, K. A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region. Genomics 80: 259-267, 2002. [PubMed: 12213195] [Full Text: https://doi.org/10.1006/geno.2002.6834]