Alternative titles; symbols
HGNC Approved Gene Symbol: FAM9C
Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38) : X:13,035,617-13,044,620 (from NCBI)
FAM9C is expressed specifically in testis (Martinez-Garay et al., 2002).
By characterizing a region of chromosome Xp22 involved in a translocation with chromosome 10, followed by EST database analysis and 5-prime RACE of a testis cDNA library, Martinez-Garay et al. (2002) cloned full-length FAM9C. The deduced 166-amino acid protein shares 65% amino acid identity with FAM9B (300478), 59% identity with FAM9A (300477), and about 30% identity with rodent Sycp3 (604759). Northern blot analysis of several tissues detected FAM9C expression only in testis. Fluorescence-tagged FAM9C localized primarily to the nucleus of transfected COS-7 cells.
Martinez-Garay et al. (2002) determined that the FAM9C gene contains 8 exons and spans about 9.0 kb.
By genomic sequence analysis, Martinez-Garay et al. (2002) mapped the FAM9C gene to chromosome Xp22.31, near the FAM9A and FAM9B genes and several pseudogenes. They also mapped related genes or pseudogenes to chromosomes Xq28, Yp11.31, 1p36.13, and 8p11.1.
Martinez-Garay, I., Jablonka, S., Sutajova, M., Steuernagel, P., Gal, A., Kutsche, K. A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region. Genomics 80: 259-267, 2002. [PubMed: 12213195] [Full Text: https://doi.org/10.1006/geno.2002.6834]