Alternative titles; symbols
HGNC Approved Gene Symbol: TLE5
Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38) : 19:3,052,910-3,062,966 (from NCBI)
In Drosophila melanogaster, neurogenesis is under the control of several loci whose products appear to determine the fate of neuroectodermal cells during embryonic development. One of these neurogenic loci is the 'enhancer of split' gene complex. Hartley et al. (1988) serendipitously isolated a mouse cDNA which predicted a sequence of 202 amino acids exhibiting strong similarity with the amino-terminal region of Drosophila enhancer of split protein. Miyasaka et al. (1993) reported the cDNA cloning, nucleotide and deduced amino acid sequencing, and tissue-specific expression of mouse and human AES (amino-terminal enhancer of split) and ESG (enhancer of split groucho) genes. (ESG is also called TLE for 'transducin-like enhancer of split'; see 600189.) Human AES transcripts of 1.6 kb and 1.4 kb were predominantly present in muscle, heart, and placenta.
Hou and Li (1998) determined that the AES gene contains 7 exons. They determined the nucleotide sequence of approximately 12 kb of AES.
Using human/Chinese hamster hybrid cell lines, Miyasaka et al. (1993) mapped the AES gene to chromosome 19. Hou and Li (1998) used fluorescence in situ hybridization to localize the AES gene to chromosome 19p13.3 near the transcription factor-3 (TCF3; 141741) gene.
Hartley, D. A., Preiss, A., Artavanis-Tsakonas, S. A deduced gene product from the Drosophila neurogenic locus, enhancer of split, shows homology to mammalian G-protein beta subunit. Cell 55: 785-795, 1988. [PubMed: 3142687] [Full Text: https://doi.org/10.1016/0092-8674(88)90134-1]
Hou, E. W., Li, S.-L. Genomic organization and chromosome localization to band 19p13.3 of the human AES gene: gene product exhibits strong similarity to the N-terminal domain of Drosophila enhancer of split Groucho protein. DNA Cell Biol. 17: 911-913, 1998. [PubMed: 9809752] [Full Text: https://doi.org/10.1089/dna.1998.17.911]
Miyasaka, H., Choudhury, B. K., Hou, E. W., Li, S. S.-L. Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. Europ. J. Biochem. 216: 343-352, 1993. [PubMed: 8365415] [Full Text: https://doi.org/10.1111/j.1432-1033.1993.tb18151.x]