Alternative titles; symbols
HGNC Approved Gene Symbol: ZNF165
Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38) : 6:28,080,282-28,089,563 (from NCBI)
Tirosvoutis et al. (1995) described a cDNA encoding a member of the zinc finger gene family (ZNF165) that was identified by analysis of EST sequences from human adult testis mRNA. The complete cDNA encodes a predicted 475-amino acid protein with an N-terminal acidic domain containing 17% aspartic and glutamic acid residues and a C-terminal domain with 5 zinc finger motifs. Northern blot analysis identified a 2.2-kb transcript specific to the testis.
By direct cDNA hybridization to YACs from region 6p21.3, Lee et al. (1997) isolated ZNF165, which they called LD65, from a cluster of zinc finger protein genes. All were members of the Kruppel family of transcriptional activators, containing a conserved C2H2 domain (see 165230). ZNF165 belongs to a subfamily of Kruppel proteins that have a 67-amino acid SCAN box and lack the A and B domains of the Kruppel-associated box (KRAB). By Northern blot analysis, Lee et al. (1997) detected low levels of ZNF165 expression in placenta, lung, liver, pancreas, spleen, thymus, and colon.
Tirosvoutis et al. (1995) mapped the ZNF165 gene to chromosome 6 by hybridization to a panel of somatic cell hybrid DNAs. They regionalized the gene to 6p21 by fluorescence in situ hybridization.
Lee, P. L., Gelbart, T., West, C., Adams, M., Blackstone, R., Beutler, E. Three genes encoding zinc finger proteins on human chromosome 6p21.3: members of a new subclass of the Kruppel gene family containing the conserved SCAN box domain. Genomics 43: 191-201, 1997. [PubMed: 9244436] [Full Text: https://doi.org/10.1006/geno.1997.4806]
Tirosvoutis, K. N., Divane, A., Jones, M., Affara, N. A. Characterization of a novel zinc finger gene (ZNF165) mapping to 6p21 that is expressed specifically in testis. Genomics 28: 485-490, 1995. [PubMed: 7490084] [Full Text: https://doi.org/10.1006/geno.1995.1178]