Alternative titles; symbols
HGNC Approved Gene Symbol: MPP3
Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38) : 17:43,800,811-43,833,146 (from NCBI)
The discs-large family is a collection of proteins first described in Drosophila that have a common structural organization and are thought to be involved in signal transduction and mediating protein-protein interactions at the cytoplasmic surface of the cell membrane. Each protein has 3 distinct structural domains: an N-terminal segment comprising one or more discs-large homologous regions (DHRs); a SRC oncogene (190090) homology motif 3 (SH3); and a C-terminal domain with homology to guanylate kinase (139270). The defining member of this group of proteins is the gene product of the Drosophila lethal discs-large-1 locus (601014), which was originally identified by the analysis of recessive lethal mutants (summary by Smith et al., 1996).
Smith et al. (1996) isolated and characterized MPP3, which they called DLG3, with the structural characteristics of the discs-large family. The putative MPP3 gene product has a molecular mass of 66 kD. The products of the MPP2 (600623) and MPP3 genes show 36% identity and 58% similarity to each other, and both show nearly 60% sequence similarity to EMP55 (305360), an erythroid phosphoprotein that is a component of the red cell membrane.
Smith et al. (1996) mapped the MMP2 gene to chromosome 17 in the same segment, 17q12-q21, as MPP2.
Smith, S. A., Holik, P., Stevens, J., Mazoyer, S., Melis, R., Williams, B., White, R., Albertsen, H. Isolation of a gene (DLG3) encoding a second member of the discs-large family on chromosome 17q12-q21. Genomics 31: 145-150, 1996. [PubMed: 8824795] [Full Text: https://doi.org/10.1006/geno.1996.0025]