Entry - *601401 - MYELOID LEUKEMIA FACTOR 2; MLF2 - OMIM

 
 
* 601401

MYELOID LEUKEMIA FACTOR 2; MLF2


Alternative titles; symbols

MYELODYSPLASIA-MYELOID LEUKEMIA FACTOR 2


HGNC Approved Gene Symbol: MLF2

Cytogenetic location: 12p13.31   Genomic coordinates (GRCh38) : 12:6,747,996-6,753,141 (from NCBI)


TEXT

▼ Cloning and Expression

Kuefer et al. (1996) described a cDNA encoding a predicted 248-amino acid protein sequence with approximately 40% identical to myeloid leukemia factor-1 (601402). Expression of MLF2 was ubiquitous.


▼ Mapping

By fluorescence in situ hybridization, Kuefer et al. (1996) mapped the MLF2 gene to chromosome 12p13, a region associated with translocations in acute leukemias of lymphoid and myeloid origin. However, they found no alterations in the structure of the MLF2 locus in patients shown to have 12p translocations.


▼ REFERENCES

  1. Kuefer, M. U., Look, A. T., Williams, D. C., Valentine, V., Naeve, C. W., Behm, F. G., Mullersman, J. E., Yoneda-Kato, N., Montgomery, K., Kucherlapati, R., Morris, S. W. cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2). Genomics 35: 392-396, 1996. [PubMed: 8661158, related citations] [Full Text]


Creation Date:
Alan F. Scott : 8/28/1996
Edit History:
carol : 03/25/2014
mark : 8/28/1996

* 601401

MYELOID LEUKEMIA FACTOR 2; MLF2


Alternative titles; symbols

MYELODYSPLASIA-MYELOID LEUKEMIA FACTOR 2


HGNC Approved Gene Symbol: MLF2

Cytogenetic location: 12p13.31   Genomic coordinates (GRCh38) : 12:6,747,996-6,753,141 (from NCBI)


TEXT

Cloning and Expression

Kuefer et al. (1996) described a cDNA encoding a predicted 248-amino acid protein sequence with approximately 40% identical to myeloid leukemia factor-1 (601402). Expression of MLF2 was ubiquitous.


Mapping

By fluorescence in situ hybridization, Kuefer et al. (1996) mapped the MLF2 gene to chromosome 12p13, a region associated with translocations in acute leukemias of lymphoid and myeloid origin. However, they found no alterations in the structure of the MLF2 locus in patients shown to have 12p translocations.


REFERENCES

  1. Kuefer, M. U., Look, A. T., Williams, D. C., Valentine, V., Naeve, C. W., Behm, F. G., Mullersman, J. E., Yoneda-Kato, N., Montgomery, K., Kucherlapati, R., Morris, S. W. cDNA cloning, tissue distribution, and chromosomal localization of myelodysplasia/myeloid leukemia factor 2 (MLF2). Genomics 35: 392-396, 1996. [PubMed: 8661158] [Full Text: https://doi.org/10.1006/geno.1996.0376]


Creation Date:
Alan F. Scott : 8/28/1996

Edit History:
carol : 03/25/2014
mark : 8/28/1996



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 16, 2024