Entry - *601959 - NIMA-RELATED KINASE 4; NEK4 - OMIM

 
 
* 601959

NIMA-RELATED KINASE 4; NEK4


Alternative titles; symbols

NEVER IN MITOSIS GENE A-RELATED KINASE 4
SERINE/THREONINE PROTEIN KINASE 2; STK2


HGNC Approved Gene Symbol: NEK4

Cytogenetic location: 3p21.1   Genomic coordinates (GRCh38) : 3:52,708,444-52,770,940 (from NCBI)


TEXT

▼ Cloning and Expression

Levedakou et al. (1994) used degenerate PCR to clone a novel serine/threonine protein kinase, termed STK2, from a human breast carcinoma cell line. The gene encodes an 841-amino acid polypeptide. Northern blot analysis revealed that the STK2 gene is expressed as 2 mRNAs of 4.0 kb and 6.8 kb in heart and several other tissues. Levedakou et al. (1994) noted that levels of STK2 mRNA remain invariant throughout the cell cycle.


▼ Mapping

By PCR amplification on DNA from a panel of monochromosomal human-rodent hybrids, Levedakou et al. (1994) mapped the STK2 gene to chromosome 3p21.1.


▼ REFERENCES

  1. Levedakou, E. N., He, M., Baptist, E. W., Craven, R. J., Cance, W. G., Welcsh, P. L., Simmons, A., Naylor, S. L., Leach, R. L., Lewis, T. B., Bowcock, A., Liu, E. T. Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. Oncogene 9: 1977-1988, 1994. [PubMed: 8208544, related citations]


Creation Date:
Jennifer P. Macke : 8/26/1997
Edit History:
carol : 03/02/2021
alopez : 06/09/2004
carol : 8/18/2003
carol : 8/13/2003
dholmes : 9/4/1997
dholmes : 8/26/1997

* 601959

NIMA-RELATED KINASE 4; NEK4


Alternative titles; symbols

NEVER IN MITOSIS GENE A-RELATED KINASE 4
SERINE/THREONINE PROTEIN KINASE 2; STK2


HGNC Approved Gene Symbol: NEK4

Cytogenetic location: 3p21.1   Genomic coordinates (GRCh38) : 3:52,708,444-52,770,940 (from NCBI)


TEXT

Cloning and Expression

Levedakou et al. (1994) used degenerate PCR to clone a novel serine/threonine protein kinase, termed STK2, from a human breast carcinoma cell line. The gene encodes an 841-amino acid polypeptide. Northern blot analysis revealed that the STK2 gene is expressed as 2 mRNAs of 4.0 kb and 6.8 kb in heart and several other tissues. Levedakou et al. (1994) noted that levels of STK2 mRNA remain invariant throughout the cell cycle.


Mapping

By PCR amplification on DNA from a panel of monochromosomal human-rodent hybrids, Levedakou et al. (1994) mapped the STK2 gene to chromosome 3p21.1.


REFERENCES

  1. Levedakou, E. N., He, M., Baptist, E. W., Craven, R. J., Cance, W. G., Welcsh, P. L., Simmons, A., Naylor, S. L., Leach, R. L., Lewis, T. B., Bowcock, A., Liu, E. T. Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. Oncogene 9: 1977-1988, 1994. [PubMed: 8208544]


Creation Date:
Jennifer P. Macke : 8/26/1997

Edit History:
carol : 03/02/2021
alopez : 06/09/2004
carol : 8/18/2003
carol : 8/13/2003
dholmes : 9/4/1997
dholmes : 8/26/1997



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 16, 2024