HGNC Approved Gene Symbol: ZNF195
Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38) : 11:3,357,927-3,379,146 (from NCBI)
Zinc finger proteins are an important class of eukaryotic DNA binding proteins (summary by Hussey et al., 1997). The zinc finger motif contains spatially conserved cysteines and histidines, which bind a zinc ion. The most common zinc finger motif is the C2H2 type, which was first identified in the Drosophila segmentation gene, Kruppel. The human genome has several hundred Kruppel-related zinc finger genes. About one-third of these human Kruppel type genes also code for a highly conserved region, the Kruppel-associated box (KRAB domain), comprising approximately 75 amino acids found at the N-terminal end. The KRAB domain is divided into A and B boxes, usually coded for by separate exons, and constitutes a potent DNA binding-dependent repression domain. Hussey et al. (1997) reported that the zinc finger gene ZNF195 contains an N-terminal KRAB domain and 14 tandemly repeated Kruppel type zinc finger motifs at its C terminus. By Northern analysis, they demonstrated expression of ZNF195 in adult heart, brain, placenta, skeletal muscle, and pancreas with a predominant transcript size of 4.3 kb. There was little expression in adult lung, liver, and kidney. In fetal lung, liver, kidney, and brain, the predominant transcript was 3.5 kb. Fetal brain also expressed a 4.3-kb transcript.
Redeker et al. (1994) mapped the cosmid containing ZNF195 to 11p15.5 by pulsed-field gel electrophoresis. Analysis of the chromosome 11p15.5 PAC sequence allowed Hussey et al. (1997) to order markers in that region. The closest ordered marker telomeric of ZNF195 was the CARS gene (123859).
Hussey, D. J., Parker, N. J., Hussey, N. D., Little, P. F. R., Dobrovic, A. Characterization of a KRAB family zinc finger gene, ZNF195, mapping to chromosome band 11p15.5. Genomics 45: 451-455, 1997. [PubMed: 9344677] [Full Text: https://doi.org/10.1006/geno.1997.4958]
Redeker, E., Hoovers, J. M., Alders, M., van Moorsel, C. J., Ivens, A. C., Gregory, S., Kalikin, L., Bliek, J., de Galan, L., van den Bogaard, R., Visser, J., van der Voort, R., Feinberg, A. P., Little, P. F. R., Westerveld, A., Mannens, M. An integrated physical map of 201 markers assigned to the short arm of human chromosome 11. Genomics 21: 538-550, 1994. [PubMed: 7959730] [Full Text: https://doi.org/10.1006/geno.1994.1312]