Alternative titles; symbols
HGNC Approved Gene Symbol: MMP17
Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38) : 12:131,828,393-131,851,771 (from NCBI)
The matrix metalloproteinases (MMPs) form a family of structurally related, zinc-dependent endopeptidases that are involved in the degradation of the extracellular matrix and basement membranes (summary by Puente et al., 1996).
Using degenerate PCR, Puente et al. (1996) cloned a cDNA encoding matrix metalloproteinase-17 (MMP17) from a human breast carcinoma cDNA library. MMP17, named MT4-MMP by the authors, encodes a deduced 518-amino acid protein that has a domain organization characteristic of the MMP family, including a prodomain with an activation locus, a zinc-binding site, and a hemopexin domain. MMP17 also has a C-terminal extension that contains a putative transmembrane domain, indicating that it is a member of the membrane-type MMP subclass (see MMP14, 600754; MMP15, 602261; MMP16, 602262). Puente et al. (1996) showed by Northern blot analysis that the MMP17 gene is expressed as a major 2.7-kb transcript in brain, leukocytes, colon, ovary, and testis. Using RT-PCR, they detected MMP17 gene expression in all breast carcinomas and breast cancer cell lines examined.
By FISH and radiation hybrid analysis, Puente et al. (1998) mapped the MMP17 gene to chromosome 12q24.3. By radiation hybrid analysis and FISH, Kinoh et al. (1999) confirmed the mapping of MMP17 to 12q24.3 and mapped the mouse homolog to chromosome 5.
Kinoh, H., Hayashita, H., Kajita, M., Okada, A., Seiki, M. Assignment of the genes for membrane-type-4 matrix metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human chromosome band 12q24.3 and membrane-type-5 matrix metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human chromosome band 20q11.2-q12, respectively, by radiation hybrid and in situ hybridization. Cytogenet. Cell Genet. 87: 97-98, 1999. [PubMed: 10640822] [Full Text: https://doi.org/10.1159/000015402]
Puente, X. S., Pendas, A. M., Llano, E., Lopez-Otin, C. Localization of the human membrane type 4-matrix metalloproteinase gene (MMP17) to chromosome 12q24. Genomics 54: 578-579, 1998. [PubMed: 9878265] [Full Text: https://doi.org/10.1006/geno.1998.5564]
Puente, X. S., Pendas, A. M., Llano, E., Velasco, G., Lopez-Otin, C. Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma. Cancer Res. 56: 944-949, 1996. [PubMed: 8640782]