Alternative titles; symbols
HGNC Approved Gene Symbol: GCHFR
Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38) : 15:40,764,068-40,767,708 (from NCBI)
Milstien et al. (1996) purified and characterized a protein in rat that bound to GTP cyclohydrolase I (600225) and exhibited tetrahydrobiopterin-dependent inhibition of that enzyme. They found that this regulatory protein, which they termed GFRP, consists of a homodimer of 9.5-kD subunits and has a molecular mass of 20 kD. Milstien et al. (1996) used peptide sequences to clone the corresponding rat cDNA which encodes an 84-amino acid polypeptide. Northern blot analysis of rat tissues revealed that a 0.8-kb GFRP transcript was expressed at relatively high levels in liver and kidney and at somewhat lower levels in testis, heart, brain, and lung. Milstien et al. (1996) suggested that GFRP may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.
Milstien, S., Jaffe, H., Kowlessur, D., Bonner, T. I. Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP. J. Biol. Chem. 271: 19743-19751, 1996. [PubMed: 8702680] [Full Text: https://doi.org/10.1074/jbc.271.33.19743]