Alternative titles; symbols
HGNC Approved Gene Symbol: ZNF354A
Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38) : 5:178,711,512-178,730,659 (from NCBI)
Kid1 (kidney, ischemia, and developmentally regulated protein-1), a putative renal transcription factor in the rat, was first reported by Witzgall et al. (1993). Expression of the Kid1 gene was detected predominantly in kidney, where it accumulates with age and is suppressed after experimental ischemic renal injury or administration of folic acid. The predicted Kid1 amino acid sequence contains Kruppel-associated box (KRAB) A and B domains in the N terminus and Kruppel-type zinc finger motifs in the C terminus. The Kid1 protein also contains a PEST sequence, which is a feature of proteins with short halflives. Because of its unique expression pattern and its ability to regulate transcription, Kid1 is thought to play an important role in regulating renal genes in the rat.
Omori et al. (1997) isolated a 2,435-bp cDNA encoding TCF17, the human homolog of mouse Tcf17 and rat Kid1. The deduced 605-amino acid sequence shows 86.0% and 87.2% identity (91.6% and 92.8% similarity) to those of rat Kid1 and mouse Tcf17, respectively. In contrast to rat Kid1, TCF17 is expressed ubiquitously, including in kidney; all human tissues examined contained a major 2.6-kb transcript and a minor 4.3-kb transcript.
By fluorescence in situ hybridization, Omori et al. (1997) mapped the human TCF17 gene to 5q35.3, a frequently reported location for cytogenetic and molecular abnormalities in renal cell carcinomas.
The gene homologous to Kid1 in the mouse, called Tcf17 for transcription factor-17, maps to chromosome 11 (Danciger et al., 1995).
Danciger, M., Brady, J., Adamson, M. C., Farber, D. B., Piatigorsky, J., Kozak, C. A. Chromosomal localization of the genes for five zinc finger proteins expressed in mouse lens. Genomics 28: 39-43, 1995. [PubMed: 7590745] [Full Text: https://doi.org/10.1006/geno.1995.1103]
Omori, Y., Kyushiki, H., Takeda, S., Suzuki, M., Kawai, A., Fujiwara, T., Takahashi, E., Nakamura, Y. Cloning, expression and mapping of a novel human zinc-finger gene TCF17 homologous to rodent Kid1. Cytogenet. Cell Genet. 78: 285-288, 1997. [PubMed: 9465904] [Full Text: https://doi.org/10.1159/000134673]
Witzgall, R., O'Leary, E., Gessner, R., Oullette, A. J., Bonventre, J. V. Kid-1, a putative renal transcription factor: regulation during ontogeny and in response to ischemia and toxic injury. Molec. Cell Biol. 13: 1933-1942, 1993. [PubMed: 8382778] [Full Text: https://doi.org/10.1128/mcb.13.3.1933-1942.1993]