Entry - *603145 - PTPRF-INTERACTING PROTEIN ALPHA-4; PPFIA4 - OMIM

 
 
* 603145

PTPRF-INTERACTING PROTEIN ALPHA-4; PPFIA4


Alternative titles; symbols

PROTEIN-TYROSINE PHOSPHATASE, RECEPTOR-TYPE, F POLYPEPTIDE-INTERACTING PROTEIN ALPHA 4
LIPRIN-ALPHA-4


HGNC Approved Gene Symbol: PPFIA4

Cytogenetic location: 1q32.1   Genomic coordinates (GRCh38) : 1:203,026,491-203,078,736 (from NCBI)


TEXT

▼ Description

PPFIA4, or liprin-alpha-4, belongs to the liprin-alpha gene family (Serra-Pages et al., 1998). See liprin-alpha-1 (LIP1, or PPFIA1; 611054) for background on liprins.


▼ Cloning and Expression

Serra-Pages et al. (1998) identified a family of genes encoding LIP1-related proteins, or liprins. The sequence of the predicted partial 500-amino acid liprin-alpha-4 protein is 75% identical to that of LIP1. Northern blot analysis revealed that the liprin-alpha-4 gene is expressed as a 7.5-kb mRNA only in heart, brain, and skeletal muscle.


▼ Mapping

Gross (2022) mapped the PPFIA4 gene to chromosome 1q32.1 based on an alignment of the PPFIA4 sequence (GenBank BC144262) with the genomic sequence (GRCh38).

▼ REFERENCES

  1. Gross, M. B. Personal Communication. Baltimore, Md. 9/2/2022.

  2. Serra-Pages, C., Medley, Q. G., Tang, M., Hart, A., Streuli, M. Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. J. Biol. Chem. 273: 15611-15620, 1998. [PubMed: 9624153, related citations] [Full Text]


Contributors:
Matthew B. Gross - updated : 09/02/2022
Creation Date:
Rebekah S. Rasooly : 10/14/1998
Edit History:
mgross : 09/02/2022
mgross : 05/23/2007
mgross : 3/16/1999
alopez : 10/23/1998
alopez : 10/14/1998

* 603145

PTPRF-INTERACTING PROTEIN ALPHA-4; PPFIA4


Alternative titles; symbols

PROTEIN-TYROSINE PHOSPHATASE, RECEPTOR-TYPE, F POLYPEPTIDE-INTERACTING PROTEIN ALPHA 4
LIPRIN-ALPHA-4


HGNC Approved Gene Symbol: PPFIA4

Cytogenetic location: 1q32.1   Genomic coordinates (GRCh38) : 1:203,026,491-203,078,736 (from NCBI)


TEXT

Description

PPFIA4, or liprin-alpha-4, belongs to the liprin-alpha gene family (Serra-Pages et al., 1998). See liprin-alpha-1 (LIP1, or PPFIA1; 611054) for background on liprins.


Cloning and Expression

Serra-Pages et al. (1998) identified a family of genes encoding LIP1-related proteins, or liprins. The sequence of the predicted partial 500-amino acid liprin-alpha-4 protein is 75% identical to that of LIP1. Northern blot analysis revealed that the liprin-alpha-4 gene is expressed as a 7.5-kb mRNA only in heart, brain, and skeletal muscle.


Mapping

Gross (2022) mapped the PPFIA4 gene to chromosome 1q32.1 based on an alignment of the PPFIA4 sequence (GenBank BC144262) with the genomic sequence (GRCh38).

REFERENCES

  1. Gross, M. B. Personal Communication. Baltimore, Md. 9/2/2022.

  2. Serra-Pages, C., Medley, Q. G., Tang, M., Hart, A., Streuli, M. Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. J. Biol. Chem. 273: 15611-15620, 1998. [PubMed: 9624153] [Full Text: https://doi.org/10.1074/jbc.273.25.15611]


Contributors:
Matthew B. Gross - updated : 09/02/2022

Creation Date:
Rebekah S. Rasooly : 10/14/1998

Edit History:
mgross : 09/02/2022
mgross : 05/23/2007
mgross : 3/16/1999
alopez : 10/23/1998
alopez : 10/14/1998



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 30, 2024