Alternative titles; symbols
HGNC Approved Gene Symbol: GTF3C1
Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38) : 16:27,460,613-27,549,913 (from NCBI)
Transcription factor IIIC (TF3C or GTF3C), a component of RNA polymerase III, is a multisubunit complex that binds B box promoter elements (summary by Lagna et al., 1994).
Lagna et al. (1994) used oligonucleotides based on protein microsequencing results to clone rat GTF3C1 and a partial human GTF3C1 cDNA.
L'Etoile et al. (1994) cloned a full-length human cDNA encoding the approximately 230-kD TF3C-alpha subunit. The cDNA encodes a 2,109-amino acid polypeptide. Though functionally similar, the yeast and human TF3C-alpha subunit proteins have little sequence homology.
By use of immunodepletion assays, Lagna et al. (1994) showed that TF3C-alpha is absolutely required for RNA polymerase III transcription of 5S RNA (180420), tRNA, and VAI RNA genes.
L'Etoile et al. (1994) showed that TF3C-alpha binds to the box B promoter element.
Gross (2014) mapped the GTF3C1 gene to chromosome 16p12.1 based on an alignment of the GTF3C1 sequence (GenBank BC137229) with the genomic sequence (GRCh37).
Gross, M. B. Personal Communication. Baltimore, Md. 6/27/2014.
L'Etoile, N. D., Fahnestock, M. L., Shen, Y., Aebersold, R., Berk, A. J. Human transcription factor IIIC box B binding subunit. Proc. Nat. Acad. Sci. 91: 1652-1656, 1994. [PubMed: 8127861] [Full Text: https://doi.org/10.1073/pnas.91.5.1652]
Lagna, G., Kovelman, R., Sukegawa, J., Roeder, R. G. Cloning and characterization of an evolutionarily divergent DNA-binding subunit of mammalian TFIIIC. Molec. Cell. Biol. 14: 3053-3064, 1994. [PubMed: 8164661] [Full Text: https://doi.org/10.1128/mcb.14.5.3053-3064.1994]