HGNC Approved Gene Symbol: ZNF202
Cytogenetic location: 11q24.1 Genomic coordinates (GRCh38) : 11:123,723,914-123,741,660 (from NCBI)
Deletions at 11q23 have been found in approximately half of breast, lung, ovarian, and cervical carcinomas as well as in melanomas, suggesting that the region harbors at least 1 tumor susceptibility gene. There are 2 distinct regions of loss of heterozygosity (LOH) at 11q23. Monaco et al. (1998) identified cDNAs corresponding to ZNF202, a gene located within LOH region 2. Alternative splicing gives rise to alpha and beta ZNF202 protein isoforms, with predicted lengths of 424 and 648 amino acids, respectively. ZNF202-beta contains 8 zinc fingers in the C-terminal region. Northern blot analysis revealed that ZNF202 is expressed as a 4- to 4.5-kb mRNA almost exclusively in testis. The gene is also expressed in breast carcinoma cell lines.
Monaco et al. (1998) determined that the ZNF202 gene contains 6 exons and spans approximately 10 kb.
Monaco et al. (1998) identified the ZNF202 gene within a region of LOH in chromosome 11q23.
Monaco, C., Helmer Citterich, M., Caprini, E., Vorechovsky, I., Russo, G., Croce, C. M., Barbanti-Brodano, G., Negrini, M. Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins. Genomics 52: 358-362, 1998. [PubMed: 9790754] [Full Text: https://doi.org/10.1006/geno.1998.5419]