Alternative titles; symbols
HGNC Approved Gene Symbol: ZNF205
Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38) : 16:3,112,586-3,120,517 (from NCBI)
The largest family of zinc finger proteins is the C2H2, or Kruppel, type. See 165220. Some members of the Kruppel family contain a conserved KRAB region that can be divided into 2 subregions, the A box and the B box. See 601742. While constructing a transcript map of the critical region of familial Mediterranean fever (see MEFV; 608107), Deng et al. (1998) isolated cDNAs encoding ZNF205, which they designated ZNF210. Sequence analysis indicated that the predicted 504-amino acid protein is a Kruppel-type zinc finger protein that contains a KRAB A box N-terminal to 8 zinc finger motifs. Northern blot analysis revealed that the 2.2-kb ZNF210 mRNA was expressed in all tissues tested. An additional transcript was detected in a number of tissues.
By analysis of clones from the MEFV region, Deng et al. (1998) determined that the ZNF205 gene is located approximately 120 kb from the MEFV gene on 16p13.3. They reported that 4 other zinc finger genes are located in the MEFV region, including ZNF200 (603231), ZNF174, and FPM315.
Deng, Z., Centola, M., Chen, X., Sood, R., Vedula, A., Fischel-Ghodsian, N., Kastner, D. L. Identification of two Kruppel-related zinc finger genes (ZNF200 and ZNF210) from human chromosome 16p13.3. Genomics 53: 97-103, 1998. [PubMed: 9787081] [Full Text: https://doi.org/10.1006/geno.1998.5430]