HGNC Approved Gene Symbol: CREBL2
Cytogenetic location: 12p13.1 Genomic coordinates (GRCh38) : 12:12,611,876-12,645,108 (from NCBI)
Systematic deletions of the short arm of chromosome 12 occur frequently in hematopoietic malignancies and suggest the involvement of a tumor suppressor gene. A commonly deleted region in 12p13, identified by fluorescence in situ hybridization analysis, is flanked by the ETV6 (600618) and CDKN1B (600778) genes. Hoornaert et al. (1998) used a hybridization selection method to isolate cDNA fragments hybridizing to a 300-kb genomic region flanked by D12S358 and CDKN1B. Using selected fragments that detected ubiquitously expressed 3.2- and 4.0-kb transcripts on a multiple-tissue Northern blot, they screened a human bone marrow cDNA library and isolated several cDNAs. They constructed a consensus cDNA sequence (GenBank AF039081) and determined that the 2 transcripts result from alternative polyadenylation. The deduced 120-amino acid protein contains a 48-residue segment showing 41% identity to the bZIP domain of DNA-binding proteins for cAMP response elements (CREs) (e.g., 123811). The authors named the novel gene CREBL2 for CRE-binding protein-like-2.
Hoornaert et al. (1998) identified the CREBL2 gene on chromosome 12p13 within a 300-kb region flanked by D12S358 and the CDKN1B gene (600778).
Hoornaert, I., Marynen, P., Baens, M. CREBL2, a novel transcript from the chromosome 12 region flanked by ETV6 and CDKN1B. Genomics 51: 154-157, 1998. [PubMed: 9693048] [Full Text: https://doi.org/10.1006/geno.1998.5366]