Alternative titles; symbols
HGNC Approved Gene Symbol: CDC14B
Cytogenetic location: 9q22.32-q22.33 Genomic coordinates (GRCh38) : 9:96,490,939-96,619,843 (from NCBI)
CDC14A (603504) is a homolog of the essential S. cerevisiae cdc14 gene. Yeast cdc14 appears to act in late nuclear division, perhaps playing a role in preparation for DNA replication during the subsequent cell cycle. By screening a human heart library with a partial CDC14A cDNA, Li et al. (1997) identified cDNAs encoding CDC14B. The predicted 454-amino acid CDC14B protein shares 85% identity with CDC14A. Both proteins contain a protein-tyrosine phosphatase domain. Using a chimeric GFP-CDC14B protein, Li et al. (1997) localized CDC14B specifically to the nucleus of mammalian cells. Northern blot analysis detected a 6-kb CDC14B mRNA in all tissues examined.
Monk et al. (2002) constructed a contig of the proximal region of chromosome 7p and noted that CDC14B is positioned on 7p between HUS1 (603760) at 7p13-p12, distally, and DDC (107930) at 7p11, proximally. However, Hartz (2012) mapped the CDC14B gene to chromosome 9q22.32-q22.33 based on an alignment of the CDC14B sequence (GenBank AF023158) with the genomic sequence (GRCh37).
Wei et al. (2011) noted that Cdc14 phosphatase is essential for mitotic exit in yeast, but that neither Cdc14a nor Cdc14b appear to be essential for mitotic exit in mammals. They found that Cdc14b -/- mice were born at the expected mendelian ratio. Cdc14b -/- mice exhibited signs of premature aging, including early development of cataracts and kyphosis, as well as a slight deficit in contextual fear conditioning. Mouse embryonic fibroblasts (MEFs) cultured from Cdc14b -/- embryos showed elevated levels of endogenous DNA damage, slow recovery following irradiation-induced DNA damage, and early senescence compared with wildtype MEFs. Wei et al. (2011) concluded that CDC14B is required for efficient DNA damage repair.
Hartz, P. A. Personal Communication. Baltimore, Md. 3/9/2012.
Li, L., Ernsting, B. R., Wishart, M. J., Lohse, D. L., Dixon, J. E. A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast. J. Biol. Chem. 272: 29403-29406, 1997. [PubMed: 9367992] [Full Text: https://doi.org/10.1074/jbc.272.47.29403]
Monk, D., Bentley, L., Hitchins, M., Myler, R. A., Clayton-Smith, J., Ismail, S., Price, S. M., Preece, M. A., Stanier, P., Moore, G. E. Chromosome 7p disruptions in Silver Russell syndrome: delineating an imprinted candidate gene region. Hum. Genet. 111: 376-387, 2002. [PubMed: 12384779] [Full Text: https://doi.org/10.1007/s00439-002-0777-4]
Wei, Z., Peddibhotla, S., Lin, H., Fang, X., Li, M., Rosen, J. M., Zhang, P. Early-onset aging and defective DNA damage response in Cdc14b-deficient mice. Molec. Cell. Biol. 31: 1470-1477, 2011. [PubMed: 21262768] [Full Text: https://doi.org/10.1128/MCB.01330-10]