Alternative titles; symbols
HGNC Approved Gene Symbol: OVGP1
Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38) : 1:111,414,319-111,427,735 (from NCBI)
A 120-kD oviductal glycoprotein is secreted into the oviductal lumen during the estrogen-dominated follicular and periovulatory phases of the menstrual cycle. Arias et al. (1994) cloned the cDNA encoding the oviductal glycoprotein. The sequence predicts a 654-amino acid polypeptide that contains 4 potential N-glycosylation sites, 2 potential N-myristoylation sites, and several potential phosphorylation sites. The sequence has approximately 50% similarity to those of a subfamily of glycosyl hydrolases. Northern blot analysis revealed a 2.4-kb message in oviduct, but none in endometrium, cervix, or a variety of other tissues. Slot blot analysis revealed that the expression of OVGP1 was highest during the late follicular phase of the menstrual cycle, suggesting that estrogen may control its expression.
Gross (2014) mapped the OVGP1 gene to chromosome 1p13.2 based on an alignment of the OVGP1 sequence (GenBank BC126177) with the genomic sequence (GRCh37).
Arias, E. B., Verhage, H. G., Jaffe, R. C. Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein. Biol. Reprod. 51: 685-694, 1994. [PubMed: 7819450] [Full Text: https://doi.org/10.1095/biolreprod51.4.685]
Gross, M. B. Personal Communication. Baltimore, Md. 5/14/2014.