Alternative titles; symbols
HGNC Approved Gene Symbol: PNMA2
Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38) : 8:26,504,701-26,513,872 (from NCBI)
In patients with cancer, symptoms of limbic and brainstem dysfunction may result from a paraneoplastic disorder. Paraneoplastic limbic or brainstem encephalitis occurs more frequently with testicular cancer than with most other cancers. By immunohistochemical and immunoblotting techniques, Voltz et al. (1999) detected antibodies in serum and cerebrospinal fluid against a 40-kD neuronal protein in 10 of 13 patients with testicular cancer and paraneoplastic limbic or brainstem encephalitis, or both. They designated the protein MA2, and found that it was selectively expressed by normal brain tissue and by the testicular tumors of the patients. MA2 shares homology with MA1 (604010), a 'brain-testis-cancer' gene related to other neoplastic syndromes and tumors (Dalmau et al., 1999).
Gross (2014) mapped the PNMA2 gene to chromosome 8p21.2 based on an alignment of the PNMA2 sequence (GenBank BC036489) with the genomic sequence (GRCh37).
Dalmau, J., Gultekin, S. H., Voltz, R., Hoard, R., DesChamps, T., Balmaceda, C., Batchelor, T., Gerstner, E., Eichen, J., Frennier, J., Posner, J. B., Rosenfeld, M. R. Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders. Brain 122: 27-39, 1999. [PubMed: 10050892] [Full Text: https://doi.org/10.1093/brain/122.1.27]
Gross, M. B. Personal Communication. Baltimore, Md. 2/27/2014.
Voltz, R., Gultekin, S. H., Rosenfeld, M. R., Gerstner, E., Eichen, J., Posner, J. B., Dalmau, J. A serologic marker of paraneoplastic limbic and brain-stem encephalitis in patients with testicular cancer. New Eng. J. Med. 340: 1788-1795, 1999. [PubMed: 10362822] [Full Text: https://doi.org/10.1056/NEJM199906103402303]