HGNC Approved Gene Symbol: ZNF90
Cytogenetic location: 19p12 Genomic coordinates (GRCh38) : 19:20,078,000-20,121,168 (from NCBI)
The ZNF90 gene encodes a zinc finger protein of the KRAB (Kruppel-associated box) subfamily (Bellefroid et al., 1993). See ZNF91 (603971) for general information on ZNFs.
By screening a cDNA library derived from a human undifferentiated embryonal carcinoma cell line with the coding sequence of the ZNF85 (603899) N-terminal nonfinger region, which spans the KRAB domain, Bellefroid et al. (1991) isolated cDNAs encoding 11 distinct KRAB zinc finger proteins, including ZNF90, which they called HTF9.
Bellefroid et al. (1993) reported the characterization of a subgroup of KRAB zinc finger proteins, named the ZNF91 family, of which ZNF90 is a member. These proteins contain a conserved linker region, called the ZNF91-related spacer region, between their N-terminal KRAB domain and their first finger unit. The authors found that members of the ZNF91 family are widely expressed in human tissues, with the highest expression in T-lymphoid cells.
By somatic cell hybrid analysis and FISH, Bellefroid et al. (1993) mapped the ZNF90 gene to 19p13.1-p12.
Bellefroid, E. J., Marine, J. C., Ried, T., Lecocq, P. J., Riviere, M., Amemiya, C., Poncelet, D. A., Coulie, P. G., de Jong, P., Szpirer, C., Ward, D. C., Martial, J. A. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. EMBO J. 12: 1363-1374, 1993. [PubMed: 8467795] [Full Text: https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0261-4189&date=1993&volume=12&issue=4&spage=1363]
Bellefroid, E. J., Poncelet, D. A., Lecocq, P. J., Revelant, O., Martial, J. A. The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. Proc. Nat. Acad. Sci. 88: 3608-3612, 1991. [PubMed: 2023909] [Full Text: https://doi.org/10.1073/pnas.88.9.3608]