HGNC Approved Gene Symbol: ZNF92
Cytogenetic location: 7q11.21 Genomic coordinates (GRCh38) : 7:65,373,855-65,401,136 (from NCBI)
Zinc finger proteins (ZNFs), such as ZNF92, bind nucleic acids and perform many key functions, the most important of which is regulating transcription (Bellefroid et al., 1991). See ZNF91 (603971) for general information on ZNFs.
By screening a cDNA library derived from a human undifferentiated embryonal carcinoma cell line with the coding sequence of the ZNF85 (603899) N-terminal nonfinger region, which spans the KRAB domain, Bellefroid et al. (1991) isolated cDNAs encoding 11 distinct KRAB zinc finger proteins, including ZNF92, which they called HTF12.
Bellefroid et al. (1993) reported the characterization of a subgroup of KRAB zinc finger proteins, named the ZNF91 family, of which ZNF92 is a member. These proteins contain a conserved linker region, called the ZNF91-related spacer region, between their N-terminal KRAB domain and their first finger unit. The authors found that members of the ZNF91 family are widely expressed in human tissues, with the highest expression in T-lymphoid cells.
By somatic cell hybrid analysis and FISH, Bellefroid et al. (1993) mapped the ZNF92 gene to chromosome 19p13.1-p12. However, Gross (2011) mapped the ZNF92 gene to chromosome 7q11.21 based on an alignment of the ZNF92 sequence (GenBank BC036439) with the genomic sequence (GRCh37).
Bellefroid, E. J., Marine, J. C., Ried, T., Lecocq, P. J., Riviere, M., Amemiya, C., Poncelet, D. A., Coulie, P. G., de Jong, P., Szpirer, C., Ward, D. C., Martial, J. A. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. EMBO J. 12: 1363-1374, 1993. [PubMed: 8467795] [Full Text: https://doi.org/10.1002/j.1460-2075.1993.tb05781.x]
Bellefroid, E. J., Poncelet, D. A., Lecocq, P. J., Revelant, O., Martial, J. A. The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. Proc. Nat. Acad. Sci. 88: 3608-3612, 1991. [PubMed: 2023909] [Full Text: https://doi.org/10.1073/pnas.88.9.3608]
Gross, M. B. Personal Communication. Baltimore, Md. 2/25/2011.