Alternative titles; symbols
HGNC Approved Gene Symbol: ZSCAN12
Cytogenetic location: 6p22.1 Genomic coordinates (GRCh38) : 6:28,378,821-28,399,747 (from NCBI)
By sequencing clones obtained from a size-fractionated brain cDNA library, Ishikawa et al. (1997) cloned ZSCAN12, which they called KIAA0426. The transcript has an Alu repeat in its 3-prime UTR. The deduced 604-amino acid protein shares significant homology with mouse Zfp96. In vitro-translated ZSCAN12 had an apparent molecular mass of 81 kD by SDS-PAGE. RT-PCR detected low ZSCAN12 expression in lung, thymus, prostate, testis, and ovary, with little to no expression in all other tissues examined.
By radiation hybrid analysis, Ishikawa et al. (1997) mapped the ZSCAN12 gene to chromosome 6.
Stumpf (2024) mapped the ZSCAN12 gene to chromosome 6p22.1 based on an alignment of the ZSCAN12 sequence (GenBank BC041661) with the genomic sequence (GRCh38).
ZSCAN12 has been referred to as ZFP96 or ZNF96 due to its homology with mouse Zfp96; however, it is distinct from the ZNF96 gene on chromosome 19 reported by Bellefroid et al. (1993).
Bellefroid, E. J., Marine, J. C., Ried, T., Lecocq, P. J., Riviere, M., Amemiya, C., Poncelet, D. A., Coulie, P. G., de Jong, P., Szpirer, C., Ward, D. C., Martial, J. A. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. EMBO J. 12: 1363-1374, 1993. [PubMed: 8467795] [Full Text: https://doi.org/10.1002/j.1460-2075.1993.tb05781.x]
Ishikawa, K., Nagase, T., Nakajima, D., Seki, N., Ohira, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 4: 307-313, 1997. [PubMed: 9455477] [Full Text: https://doi.org/10.1093/dnares/4.5.307]
Stumpf, A. M. Personal Communication. Baltimore, Md. 08/21/2024.