Alternative titles; symbols
HGNC Approved Gene Symbol: ZNF107
Cytogenetic location: 7q11.21 Genomic coordinates (GRCh38) : 7:64,666,133-64,711,577 (from NCBI)
Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. See ZNF91 (603971) for general information on ZNFs.
By PCR-based screening of a human genomic YAC library using degenerate oligonucleotides corresponding to a consensus sequence of the spacer region of ZNF91 family members, Bellefroid et al. (1993) identified 23 distinct ZNF91-related genes, including ZNF107. They demonstrated that members of the ZNF91 family are widely expressed in human tissues, with the highest expression in T-lymphoid cells.
By sequence analysis of a human aorta-specific cDNA, followed by 5-prime RACE of human brain cDNA, Li et al. (1999) cloned ZNF107, which they called ZFD25. The deduced 783-amino acid protein has a calculated molecular mass of 90.67 kD and contains 25 C2H2-type zinc fingers. ZNF107 shares 70% homology with both ZNF91 and ZNF117 (194624). The 5-prime untranslated region contains a KRAB domain. Northern blot analysis detected a 6.2-kb transcript in human brain, heart, skeletal muscle, kidney, and pancreas. RT-PCR analysis detected expression in human aorta, liver, lung, and cultured umbilical vein endothelial cells, umbilical artery smooth muscle cells, and HepG2 cells.
Li et al. (1999) showed that ZNF107 expression in cultured human umbilical vein endothelial cells decreased in response to a shift from 20% fetal calf serum to serum-free media. They suggested that ZNF107 may play a role in serum-dependent cellular processes, such as cell proliferation and survival.
By FISH, Bellefroid et al. (1993) mapped a YAC clone containing the ZNF107 gene to 7q11.2.
Bellefroid, E. J., Marine, J. C., Ried, T., Lecocq, P. J., Riviere, M., Amemiya, C., Poncelet, D. A., Coulie, P. G., de Jong, P., Szpirer, C., Ward, D. C., Martial, J. A. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. EMBO J. 12: 1363-1374, 1993. [PubMed: 8467795] [Full Text: https://doi.org/10.1002/j.1460-2075.1993.tb05781.x]
Li, X.-A., Kokame, K., Okubo, K., Shimokado, K., Tsukamoto, Y., Miyata, T., Kato, H., Yutani, C. Cloning and characterization of a novel human gene encoding a zinc finger protein with 25 fingers. Biochim. Biophys. Acta 1489: 405-412, 1999. [PubMed: 10673043] [Full Text: https://doi.org/10.1016/s0167-4781(99)00206-7]