Entry - *603996 - ZINC FINGER PROTEIN 114; ZNF114 - OMIM

 
 
* 603996

ZINC FINGER PROTEIN 114; ZNF114


HGNC Approved Gene Symbol: ZNF114

Cytogenetic location: 19q13.33   Genomic coordinates (GRCh38) : 19:48,270,081-48,287,608 (from NCBI)


TEXT

▼ Description

Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. See ZNF91 (603971) for general information on ZNFs.

▼ Cloning and Expression

Using probes derived from a ZNF91 cDNA to screen a pool of human chromosome 19-specific cosmids that had hybridized to a degenerate oligonucleotide corresponding to the H/C link region, Bellefroid et al. (1993) isolated the genes of several distinct ZNF91 subfamily members, including ZNF114. They found that ZNF91-related genes are widely expressed in human tissues, with the highest expression levels detected in T-lymphoid cells.


▼ REFERENCES

  1. Bellefroid, E. J., Marine, J. C., Ried, T., Lecocq, P. J., Riviere, M., Amemiya, C., Poncelet, D. A., Coulie, P. G., de Jong, P., Szpirer, C., Ward, D. C., Martial, J. A. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. EMBO J. 12: 1363-1374, 1993. [PubMed: 8467795, related citations] [Full Text]


Creation Date:
Patti M. Sherman : 7/9/1999
Edit History:
carol : 03/30/2021
psherman : 07/20/1999
mgross : 7/13/1999
psherman : 7/9/1999

* 603996

ZINC FINGER PROTEIN 114; ZNF114


HGNC Approved Gene Symbol: ZNF114

Cytogenetic location: 19q13.33   Genomic coordinates (GRCh38) : 19:48,270,081-48,287,608 (from NCBI)


TEXT

Description

Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. See ZNF91 (603971) for general information on ZNFs.

Cloning and Expression

Using probes derived from a ZNF91 cDNA to screen a pool of human chromosome 19-specific cosmids that had hybridized to a degenerate oligonucleotide corresponding to the H/C link region, Bellefroid et al. (1993) isolated the genes of several distinct ZNF91 subfamily members, including ZNF114. They found that ZNF91-related genes are widely expressed in human tissues, with the highest expression levels detected in T-lymphoid cells.


REFERENCES

  1. Bellefroid, E. J., Marine, J. C., Ried, T., Lecocq, P. J., Riviere, M., Amemiya, C., Poncelet, D. A., Coulie, P. G., de Jong, P., Szpirer, C., Ward, D. C., Martial, J. A. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. EMBO J. 12: 1363-1374, 1993. [PubMed: 8467795] [Full Text: https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0261-4189&date=1993&volume=12&issue=4&spage=1363]


Creation Date:
Patti M. Sherman : 7/9/1999

Edit History:
carol : 03/30/2021
psherman : 07/20/1999
mgross : 7/13/1999
psherman : 7/9/1999



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 17, 2024