HGNC Approved Gene Symbol: ZNF131
Cytogenetic location: 5p12 Genomic coordinates (GRCh38) : 5:43,120,914-43,176,324 (from NCBI)
Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. One abundant class of such transcriptional regulators resembles the Drosophila Kruppel segmentation gene product due to the presence of repeated cys2-his2 (C2H2) zinc finger domains that are connected by conserved sequences, called H/C links. By screening a human insulinoma cDNA library with a degenerate oligonucleotide corresponding to the H/C linker sequence, Tommerup et al. (1993) isolated cDNAs potentially encoding zinc finger proteins. Tommerup and Vissing (1995) performed sequence analysis on a number of these cDNAs and identified several novel zinc finger protein genes, including ZNF131. The partial ZNF131 cDNA predicts a protein belonging to the Kruppel family of zinc finger proteins.
By transfecting HEK293 cells with epitope-tagged protein, Oh and Chung (2013) found that ZNF131 was expressed in a diffuse nuclear distribution, with exclusion from nucleoli. They found that ZNF131 was modified by ubiquitination and sumoylation.
Using yeast 2-hybrid analysis of a human fetal brain cDNA library, Oh and Chung (2013) found that ZNF131 interacted with UHRF2 (615211), a dual-function ubiquitin and SUMO E3 ligase. Coimmunoprecipitation analysis of transfected HEK293 cells confirmed the interaction. UHRF2 did not affect ZNF131 ubiquitination, but functioned as a SUMO E3 ligase and sumoylated ZNF131 on lys567 in a dose-dependent manner. Both sumoylation and ubiquitination of ZNF131 were enhanced in the presence of a proteasome inhibitor.
By FISH, Tommerup and Vissing (1995) mapped the ZNF131 gene to chromosome 5p12-p11.
Oh, Y., Chung, K. C. UHRF2, a ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131. J. Biol. Chem. 288: 9102-9111, 2013. [PubMed: 23404503] [Full Text: https://doi.org/10.1074/jbc.M112.438234]
Tommerup, N., Aagaard, L., Lund, C. L., Boel, E., Baxendale, S., Bates, G. P., Lehrach, H., Vissing, H. A zinc-finger gene ZNF141 mapping at 4p16.3/D4S90 is a candidate gene for the Wolf-Hirschhorn (4p-) syndrome. Hum. Molec. Genet. 2: 1571-1575, 1993. [PubMed: 8268908] [Full Text: https://doi.org/10.1093/hmg/2.10.1571]
Tommerup, N., Vissing, H. Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders. Genomics 27: 259-264, 1995. [PubMed: 7557990] [Full Text: https://doi.org/10.1006/geno.1995.1040]