Alternative titles; symbols
HGNC Approved Gene Symbol: IL1RL2
Cytogenetic location: 2q12.1 Genomic coordinates (GRCh38) : 2:102,186,973-102,243,086 (from NCBI)
IL1RL2 encodes a receptor for interleukin-36 (IL36; see 605509) cytokines (Medina-Contreras et al., 2016).
Using a homology-based PCR approach to identify IL1 receptor (IL1R1; 147810)-related genes, Lovenberg et al. (1996) identified a cDNA, which they called IL1RRP2, that encodes a 561-amino acid protein with significant sequence identity to IL1R1.
Dale and Nicklin (1999) showed by radiation hybrid mapping that IL1R2 (147811), IL1R1, IL1RL2, IL1RL1 (601203), and IL18R1 (604494) map to chromosome 2q12 and are transcribed in the same direction, with IL1R2 being transcribed towards the cluster.
Lovenberg et al. (1996) found that, like IL1RRP (604494), IL1RRP2 failed to bind IL1-alpha (147760) or IL1-beta (147720).
Medina-Contreras et al. (2016) observed that colonic lamina propria cells of mice treated with dextran sodium sulfate (DSS) expressed abundant Il36g (605542), but not Il36a (605509) or Il36b (605508). IL36G expression was also increased in human colonic mucosa of patients with inflammatory bowel disease (IBD; see 266600) compared with controls. Following DSS treatment, mice lacking Il1rl2, which encodes Il36 receptor, had progressive disease with shortened and inflamed colons, whereas wildtype mice eventually recovered from colitis. Failure to repair colonic wound in Il1rl2 -/- mice was associated with reduced neutrophil accumulation. Il22 (605330) production increased after the peak of Il36g in wildtype mice, but not Il1rl2 -/- mice, following DSS treatment. Treatment of Il1rl2 -/- mice with an agonist of aryl hydrocarbon receptor (AHR; 600253) during DSS treatment enhanced Il22 production and enabled recovery from intestinal damage. Medina-Contreras et al. (2016) concluded that the IL36/IL36R axis is important in the repair of intestinal mucosal wounds and that neutrophils have a central role in the process.
Dale, M., Nicklin, M. J. Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q. Genomics 57: 177-179, 1999. [PubMed: 10191101] [Full Text: https://doi.org/10.1006/geno.1999.5767]
Lovenberg, T. W., Crowe, P. D., Liu, C., Chalmers, D. T., Liu, X. J., Liaw, C., Clevenger, W., Oltersdorf, T., De Souza, E. B., Maki, R. A. Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1R-rp2). J. Neuroimmun. 70: 113-122, 1996. [PubMed: 8898719] [Full Text: https://doi.org/10.1016/s0165-5728(96)00047-1]
Medina-Contreras, O., Harusato, A., Nishio, H., Flannigan, K. L., Ngo, V., Leoni, G., Neumann, P.-A., Geem, D., Lili, L. N., Ramadas, R. A., Chassaing, B., Gewirtz, A. T., Kohlmeier, J. E., Parkos, C. A., Towne, J. E., Nusrat, A., Denning, T. L. Cutting edge: IL-36 receptor promotes resolution of intestinal damage. J. Immun. 196: 34-38, 2016. [PubMed: 26590314] [Full Text: https://doi.org/10.4049/jimmunol.1501312]