Alternative titles; symbols
HGNC Approved Gene Symbol: TESK2
Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38) : 1:45,343,883-45,491,163 (from NCBI)
Protein kinases are involved in intracellular signal transduction pathways. They are broadly classified into serine/threonine kinases and tyrosine kinases, which can be further divided into families and subfamilies based on similarity within the catalytic domain. Using a subtractive PCR cloning strategy and degenerate primers based on conserved amino acid regions in the catalytic domain of serine/threonine kinases, Rosok et al. (1999) isolated a novel full-length cDNA from a human fetal liver cDNA library. They designated the cDNA TESK2 because it encodes a putative 555-amino acid protein with a kinase domain that is 65% identical to that of TESK1 (601782), which exhibits dual specific protein kinase activity on both serine/threonine and tyrosine; it also shows 42% and 39% identity to LIMK1 (601329) and LIMK2 (601988), respectively. Northern blot analysis revealed a single TESK2 mRNA species of approximately 3.0 kb, predominantly expressed in testis and prostate. Rosok et al. (1999) found that the rat homolog was first expressed in the testis after day 30 of postnatal development in round spermatids. They suggested that TESK2 plays an important role in spermatogenesis.
By fluorescence in situ hybridization, Rosok et al. (1999) mapped the TESK2 gene to chromosome 1p32.
Rosok, O., Pedeutour, F., Ree, A. H., Aasheim, H.-C. Identification and characterization of TESK2, a novel member of the LIMK/TESK family of protein kinases, predominantly expressed in testis. Genomics 61: 44-54, 1999. [PubMed: 10512679] [Full Text: https://doi.org/10.1006/geno.1999.5922]