Alternative titles; symbols
HGNC Approved Gene Symbol: ZNF234
Cytogenetic location: 19q13.31 Genomic coordinates (GRCh38) : 19:44,141,554-44,160,313 (from NCBI)
Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (604749) for additional information on zinc finger proteins. By screening a human monoblast cell line (U-937) cDNA library with a degenerate oligonucleotide based on a conserved region of Kruppel-related zinc finger proteins that encompasses the H/C link, Abrink et al. (1995) isolated cDNAs encoding 42 distinct Kruppel-related zinc finger proteins, including ZNF234, which they called HZF4. The ZNF234 cDNA lacks start and stop codons; however, the authors stated that the coding sequence is probably minimally incomplete at both the 5-prime and 3-prime ends. The predicted ZNF234 protein, which consists of more than 695 amino acids, contains a KRAB A domain in the N terminus; a short spacer region, which does not share sequence similarity with the spacer regions of ZNF91 (603971) subfamily members; and a degenerate zinc finger motif followed by 18 canonical zinc finger motifs. Northern blot analysis detected a major 4.5-kb ZNF234 transcript in HeLa cells, U-937 cells, and PMA-induced U-937 cells.
Abrink, M., Aveskogh, M., Hellman, L. Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937. DNA Cell Biol. 14: 125-136, 1995. [PubMed: 7865130] [Full Text: https://doi.org/10.1089/dna.1995.14.125]