Alternative titles; symbols
HGNC Approved Gene Symbol: PLAGL2
Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38) : 20:32,192,504-32,207,743 (from NCBI)
By screening a human fetal kidney cDNA library with EST sequences showing homology to PLAG1 (603026), a developmentally regulated C2H2 zinc finger gene, Kas et al. (1998) isolated a cDNA, which they designated PLAGL2, encoding a 496-amino acid protein. Sequence analysis of PLAGL2 showed at least 6 zinc fingers in the N-terminal region and a proline- and serine-rich C terminus. The N terminus of PLAGL2 is very similar to that of PLAGL1 (603044) and PLAG1 but the C-terminal regions are rather divergent. Northern blot analysis revealed expression of 7.5-kb major and 2.5-kb minor PLAGL2 transcripts in fetal kidney, liver, lung, and brain but not in adult tissues. The authors determined that PLAGL2 and PLAG1 have only weak transactivational capacity compared to the strong activity of PLAGL1.
Stumpf (2024) mapped the PLAGL2 gene to chromosome 20q11.21 based on an alignment of the PLAGL2 sequence (GenBank D83784) with the genomic sequence (GRCh38).
Kas, K., Voz, M. L., Hensen, K., Meyen, E., Van de Ven, W. J. Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. J. Biol. Chem. 273: 23026-23032, 1998. [PubMed: 9722527] [Full Text: https://doi.org/10.1074/jbc.273.36.23026]
Stumpf, A. M. Personal Communication. Baltimore, Md. 06/10/2024.