HGNC Approved Gene Symbol: PILRB
Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38) : 7:100,358,117-100,367,831 (from NCBI)
By 5-prime RACE analysis of PILRA (605341), Mousseau et al. (2000) identified a cDNA encoding PILRB. PILRB encodes a protein with similar extracellular features as PILRA but has a short cytoplasmic tail and a charged lysine residue within its transmembrane domain, suggesting that it may be an activating rather than an inhibitory receptor. RT-PCR analysis indicated that PILRA and PILRB are expressed, or paired, at the mRNA level in various tissues.
Shiratori et al. (2004) cloned and characterized mouse Pilrb.
Shiratori et al. (2004) identified a novel CD99 (313470)-like ligand for mouse Pilrb that they termed Pilrl. Cells expressing Pilrl specifically activated natural killer cells and dendritic cells expressing Pilrb.
By genomic sequence analysis, Mousseau et al. (2000) determined that the PILRB gene contains only 4 exons spanning approximately 9.8 kb, whereas PILRA has 7 exons.
By long-range PCR on genomic DNA and comparison to a chromosome 7 segment (GenBank RG161A02), Mousseau et al. (2000) mapped the PILRB gene to chromosome 7, 5.6 kb upstream from PILRA.
Mousseau, D. D., Banville, D., L'Abbe, D., Bouchard, P., Shen, S.-H. PILR-alpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILR-beta. J. Biol. Chem. 275: 4467-4474, 2000. [PubMed: 10660620] [Full Text: https://doi.org/10.1074/jbc.275.6.4467]
Shiratori, I., Ogasawara, K., Saito, T., Lanier, L. L., Arase, H. Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor. J. Exp. Med. 199: 525-533, 2004. [PubMed: 14970179] [Full Text: https://doi.org/10.1084/jem.20031885]