Alternative titles; symbols
HGNC Approved Gene Symbol: DKKL1
Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38) : 19:49,360,515-49,375,116 (from NCBI)
For background information on WNT and Dickkopf proteins, see WNT6 (604663) and DKK1 (605189).
By complete sequencing of an IMAGE clone, Krupnik et al. (1999) identified a cDNA encoding a Dickkopf-related protein they termed 'soggy,' or SGY. The deduced 242-amino acid SGY protein, which is 22% identical to DKK3 (605416) and 59% identical to the mouse Sgy sequence, possesses 2 potential N-glycosylation sites. Northern blot and in situ hybridization analysis revealed expression of a 1.0-kb Sgy transcript in adult mouse testis and day-11 and -15 embryos. Western blot analysis showed that SGY is secreted as a 40- to 50-kD protein; deglycosylation reduced the protein by 5 to 10 kD. Functional analysis determined that SGY does not block Xenopus Wnt8, Wnt3a, or Wnt2b induction of a secondary axis in frog embryos.
Scott (2000) mapped the SGY gene to chromosome 19 based on sequence similarity between the SGY sequence (GenBank AF177398) and the chromosome 19 clones LLNLR-254A7 (GenBank AC010643) and LLNLR-278H5 (GenBank AC010524).
Krupnik, V. E., Sharp, J. D., Jiang, C., Robison, K., Chickering, T. W., Amaravadi, L., Brown, D. E., Guyot, D., Mays, G., Leiby, K., Chang, B., Duong, T., Goodearl, A. D. J., Gearing, D. P., Sokol, S. Y., McCarthy, S. A. Functional and structural diversity of the human Dickkopf gene family. Gene 238: 301-313, 1999. [PubMed: 10570958] [Full Text: https://doi.org/10.1016/s0378-1119(99)00365-0]
Scott, A. F. Personal Communication. Baltimore, Md. 11/22/2000.