Alternative titles; symbols
HGNC Approved Gene Symbol: ARIH2
Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38) : 3:48,918,842-48,986,382 (from NCBI)
Zinc-binding cysteine and histidine residues that form a 3-dimensional structure, stabilized by zinc, are found in protein-interacting motifs in LIM (e.g., LMO1; 186921), RING (e.g., RING1; 602045), or LAP (e.g., AF10; 602409) finger-containing proteins. Van der Reijden et al. (1999) identified ARIH2, which they termed TRIAD1, a 493-amino acid nuclear protein upregulated during retinoic acid-induced granulocytic differentiation of acute promyelocytic leukemia cells. ARIH2 contains 2 RING fingers flanking a conserved cysteine-rich (C6HC) domain the authors designated DRIL (double RING finger-linked domain); 2 C-terminal coiled-coil domains; and an acidic N-terminal region. The DRIL domain with its 2 flanking RING fingers, collectively referred to by the authors as the TRIAD (2 RING fingers and DRIL) domain, spans approximately 200 amino acids and was identified, with a preserved order and distance, in more than 20 eukaryotic proteins.
The International Radiation Hybrid Mapping Consortium mapped the ARIH2 gene to chromosome 3 (WI-11545).
van der Reijden, B. A., Erpelinck-Verschueren, C. A. J., Lowenberg, B., Jansen, J. H. TRIADs: a new class of proteins with a novel cysteine-rich signature. Protein Sci. 8: 1557-1561, 1999. [PubMed: 10422847] [Full Text: https://doi.org/10.1110/ps.8.7.1557]