Entry - *605886 - COMPLEMENT COMPONENT RECEPTOR 1-LIKE; CR1L - OMIM

 
 
* 605886

COMPLEMENT COMPONENT RECEPTOR 1-LIKE; CR1L


Alternative titles; symbols

COMPLEMENT COMPONENT 3b/4b RECEPTOR-LIKE


HGNC Approved Gene Symbol: CR1L

Cytogenetic location: 1q32.2   Genomic coordinates (GRCh38) : 1:207,645,133-207,723,703 (from NCBI)


TEXT

▼ Cloning and Expression

The C3b/C4b receptor (CR1; 120620) is important in immune complex processing. On phagocytic cells it promotes the adherence and sometimes the endocytosis of C3b- and C4b-coated particles. CR1 is composed largely of a tandemly repeated motif of approximately 60 amino acids, the short consensus repeat (SCR). In the course of cloning genomic CR1 sequences, Hourcade et al. (1990) identified a related gene, CR1L. Analysis of subclones identified 10 exons encoding a signal peptide and SCR1 through SCR6 and SCR9, which are 91% homologous to the corresponding N-terminal regions of the CR1 protein. Hourcade et al. (1990) concluded that CR1L arose by a gene duplication event and has undergone mutation at the beginning of SCR1.


▼ Mapping

By genomic sequence analysis, Hourcade et al. (1990) mapped the CR1L gene to chromosome 1q32.


▼ REFERENCES

  1. Hourcade, D., Miesner, D. R., Bee, C., Zeldes, W., Atkinson, J. P. Duplication and divergence of the amino-terminal coding region of the complement receptor 1 (CR1) gene: an example of concerted (horizontal) evolution within a gene. J. Biol. Chem. 265: 974-980, 1990. [PubMed: 2295627, related citations]


Creation Date:
Paul J. Converse : 4/27/2001
Edit History:
carol : 03/31/2021
mgross : 04/27/2001

* 605886

COMPLEMENT COMPONENT RECEPTOR 1-LIKE; CR1L


Alternative titles; symbols

COMPLEMENT COMPONENT 3b/4b RECEPTOR-LIKE


HGNC Approved Gene Symbol: CR1L

Cytogenetic location: 1q32.2   Genomic coordinates (GRCh38) : 1:207,645,133-207,723,703 (from NCBI)


TEXT

Cloning and Expression

The C3b/C4b receptor (CR1; 120620) is important in immune complex processing. On phagocytic cells it promotes the adherence and sometimes the endocytosis of C3b- and C4b-coated particles. CR1 is composed largely of a tandemly repeated motif of approximately 60 amino acids, the short consensus repeat (SCR). In the course of cloning genomic CR1 sequences, Hourcade et al. (1990) identified a related gene, CR1L. Analysis of subclones identified 10 exons encoding a signal peptide and SCR1 through SCR6 and SCR9, which are 91% homologous to the corresponding N-terminal regions of the CR1 protein. Hourcade et al. (1990) concluded that CR1L arose by a gene duplication event and has undergone mutation at the beginning of SCR1.


Mapping

By genomic sequence analysis, Hourcade et al. (1990) mapped the CR1L gene to chromosome 1q32.


REFERENCES

  1. Hourcade, D., Miesner, D. R., Bee, C., Zeldes, W., Atkinson, J. P. Duplication and divergence of the amino-terminal coding region of the complement receptor 1 (CR1) gene: an example of concerted (horizontal) evolution within a gene. J. Biol. Chem. 265: 974-980, 1990. [PubMed: 2295627]


Creation Date:
Paul J. Converse : 4/27/2001

Edit History:
carol : 03/31/2021
mgross : 04/27/2001



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 16, 2024