Alternative titles; symbols
HGNC Approved Gene Symbol: STAU2
Cytogenetic location: 8q21.11 Genomic coordinates (GRCh38) : 8:73,420,369-73,747,480 (from NCBI)
The STAU2 gene encodes a protein homologous to both human STAU1 (601716) and Drosophila staufen, a double-stranded RNA-binding protein required both for the localization of maternal determinants to the posterior pole of the Drosophila egg and for bicoid RNA to localize correctly to the anterior pole (summary by Buchner et al., 1999).
Buchner et al. (1999) determined that a transcriptional unit thought to map to chromosome Xp showed 100% sequence homology with a cDNA clone mapped to chromosome 8q13-q21. Using a segment of this clone to screen a neural precursor cell cDNA library, they cloned the full-length cDNA, the sequence of which matched 2 ESTs on chromosome 8q13-q21.1. A related sequence matched an EST on chromosome Xq, but was considered to be a pseudogene. The full-length cDNA on chromosome 8, designated STAU2, encodes a deduced 479-amino acid protein that shares 48.5% and 59.9% similarity to the Drosophila staufen and the human staufen-1 (STAU; 601716) proteins, respectively. The STAU2 protein contains 3 predicted double-stranded RNA-binding domains (dsRBDs), including a conserved dsRBD, present in Drosophila staufen and human STAU, which has been demonstrated to be responsible for RNA binding. Using the full-length STAU2 cDNA as query, Buchner et al. (1999) identified 40 different ESTs derived from different tissues, demonstrating that STAU2 is ubiquitously expressed.
By sequence analysis, Buchner et al. (1999) mapped the STAU2 gene to chromosome 8q13-q21.
Buchner, G., Bassi, M. T., Andolfi, G., Ballabio, A., Franco, B. Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region. Genomics 62: 113-118, 1999. [PubMed: 10585778] [Full Text: https://doi.org/10.1006/geno.1999.6015]