Entry - *605973 - DDB1- AND CUL4-ASSOCIATED FACTOR 7; DCAF7 - OMIM

 
 
* 605973

DDB1- AND CUL4-ASSOCIATED FACTOR 7; DCAF7


Alternative titles; symbols

AN11, PETUNIA, HOMOLOG OF; AN11


HGNC Approved Gene Symbol: DCAF7

Cytogenetic location: 17q23.3   Genomic coordinates (GRCh38) : 17:63,550,477-63,594,266 (from NCBI)


TEXT

▼ Cloning and Expression

The An1, An2, and An11 loci control the pigmentation of petunias by stimulating transcription of anthocyanin genes. By Southern blot analysis with a petunia An11 probe, followed by EST database searching and PCR, de Vetten et al. (1997) obtained a cDNA encoding human AN11. The deduced 342-amino acid, WD repeat-containing protein is 53% identical to the petunia An11 protein and is conserved in worms and yeast, which do not produce anthocyanins. Functional analysis showed that human AN11 could partially complement a petunia An11 mutant. De Vetten et al. (1997) concluded that An11 is involved in signal transduction in petunias.


▼ REFERENCES

  1. de Vetten, N., Quattrocchio, F., Mol, J., Koes, R. The an11 locus controlling flower pigmentation in petunia encodes a novel WD-repeat protein conserved in yeast, plants, and animals. Genes Dev. 11: 1422-1434, 1997. [PubMed: 9192870, related citations] [Full Text]


Creation Date:
Paul J. Converse : 5/25/2001
Edit History:
alopez : 03/27/2012
mgross : 5/25/2001

* 605973

DDB1- AND CUL4-ASSOCIATED FACTOR 7; DCAF7


Alternative titles; symbols

AN11, PETUNIA, HOMOLOG OF; AN11


HGNC Approved Gene Symbol: DCAF7

Cytogenetic location: 17q23.3   Genomic coordinates (GRCh38) : 17:63,550,477-63,594,266 (from NCBI)


TEXT

Cloning and Expression

The An1, An2, and An11 loci control the pigmentation of petunias by stimulating transcription of anthocyanin genes. By Southern blot analysis with a petunia An11 probe, followed by EST database searching and PCR, de Vetten et al. (1997) obtained a cDNA encoding human AN11. The deduced 342-amino acid, WD repeat-containing protein is 53% identical to the petunia An11 protein and is conserved in worms and yeast, which do not produce anthocyanins. Functional analysis showed that human AN11 could partially complement a petunia An11 mutant. De Vetten et al. (1997) concluded that An11 is involved in signal transduction in petunias.


REFERENCES

  1. de Vetten, N., Quattrocchio, F., Mol, J., Koes, R. The an11 locus controlling flower pigmentation in petunia encodes a novel WD-repeat protein conserved in yeast, plants, and animals. Genes Dev. 11: 1422-1434, 1997. [PubMed: 9192870] [Full Text: https://doi.org/10.1101/gad.11.11.1422]


Creation Date:
Paul J. Converse : 5/25/2001

Edit History:
alopez : 03/27/2012
mgross : 5/25/2001



NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: Nov. 16, 2024