HGNC Approved Gene Symbol: MYNN
Cytogenetic location: 3q26.2 Genomic coordinates (GRCh38) : 3:169,773,396-169,789,716 (from NCBI)
A novel class of structurally related zinc finger proteins, including myoneurin, characterized by a classic C2H2 zinc finger motif and a BTB/POZ protein-protein interaction domain, has been implicated in the control of a wide range of developmental events in Drosophila and mammals (summary by Alliel et al., 2000).
Alliel et al. (2000) cloned a member of the BTB/POZ-ZF class, which they called myoneurin, from a human testicular cDNA library and identified the mouse homolog. The MYNN cDNA encodes a deduced 610-amino acid protein that shares 95% sequence identity with the mouse protein. Between the BTB/POZ domain in the N terminus and 8 tandemly repeated zinc finger motifs of the Kruppel type in the C terminus, myoneurin has 2 potential nuclear localization signals. Northern blot analysis detected a major 2.5-kb transcript predominantly in muscle and more weakly in other tissues including testis, ovary, and placenta. Two less abundant transcripts of 3.3 and over 5.0 kb were also identified in muscle and appeared to be underexpressed in testis and overexpressed in thymus, respectively.
Alliel, P. M., Seddiqi, N., Goudou, D., Cifuentes-Diaz, C., Romero, N., Velasco, E., Rieger, F., Perin, J.-P. Myoneurin, a novel member of the BTB/POZ-zinc finger family highly expressed in human muscle. Biochem. Biophys. Res. Commun. 273: 385-391, 2000. [PubMed: 10873615] [Full Text: https://doi.org/10.1006/bbrc.2000.2862]